Teniposide - Moligand™, 10mM in DMSO , DNA topoisomerase II inhibitor, CAS No.29767-20-2, DNA topoisomerase II inhibitor

CAS: 29767-20-2 Cat. No.: T408960 분자식: C₃₂H₃₂O₁₃S 분자량: 656.65 EC 번호: 249-831-2 PubChem CID: 452548

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 122819, VM-26 | (5R,​5aR,​8aR,​9S)​-5,​8,​8a,​9-​tetrahydro-​5-​(4-​hydroxy-​3,​5-​dimethoxyphenyl)​-​9-​[[4,​6-​O-​[(R)​-​2-​thienylmethylene]​-​β-​D-​glucopyranosyl]​oxy]​-furo[3',​4':6,​7]​naphtho[2,​3-​d]​-​1,​3-​dioxol-​6(5aH)​-​one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Teniposide (NSC 122819, VM-26) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).
In vitro

In vivo

Cell Data

cell lines：Fischer rat thyroid (FRT) cells

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

동의어

NSC 122819, VM-26 | (5R,​5aR,​8aR,​9S)​-5,​8,​8a,​9-​tetrahydro-​5-​(4-​hydroxy-​3,​5-​dimethoxyphenyl)​-​9-​[[4,​6-​O-​[(R)​-​2-​thienylmethylene]​-​β-​D-​glucopyranosyl]​oxy]​-furo[3',​4':6,​7]​naphtho[2,​3-​d]​-​1,​3-​dioxol-​6(5aH)​-​one

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Teniposide (NSC 122819, VM-26) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

DNA topoisomerase II inhibitor

제품 특성

• ALogP: 1.2

이름과 식별자

• 이성체 SMILES: COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)CO[C@H](O7)C8=CC=CS8)O)O
• PubChem CID: 452548
• 분자량: 656.65

관련 대상(인간)

TOP2A Tclin DNA topoisomerase 2-alpha (0 Activities)

Discover Target: TOP2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 47 mg/mL (201.11 mM); Water: Insoluble; Ethanol: Insoluble
• 특정 회전[α]: -111° (C=1,CHCl3:MeOH=9:1)
• 녹는점(°C): 247 °C(dec.)

참고 문헌

1. Yifan Wu, Xiaoxia Gong, Jianzhong Shen, Kui Zhu.  (2023)  Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.  Journal of Advanced Research,      [PMID:37290606] [10.1016/j.jare.2023.05.010]

2. Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao, Zhengbao Zha.  (2020)  Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants.  DRUG DELIVERY,      [PMID:32611260] [10.1080/10717544.2020.1787558]