Terbinafine - 10mM in DMSO , Squalene monooxygenase inhibitor, CAS No.91161-71-6, Squalene monooxygenase inhibitor

CAS: 91161-71-6 Cat. No.: T409060 분자식: C₂₁H₂₅N 분자량: 291.43 EC 번호: 618-706-8 PubChem CID: 1549008

등급 & 순도 10mM in DMSO

Synonyms

SF 86-327 | N-​[(2E)​-​6,​6-​dimethyl-​2-​hepten-​4-​yn-​1-​yl]​-​N-​methyl-1-​naphthalenemethanami​ne

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Terbinafine Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
In vitro

Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). Terbinafine inhibits dextromethorphan O-demethylation with an apparent K_i ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest.

In vivo

Cell Data

cell lines：HUVECs

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

SF 86-327 | N-​[(2E)​-​6,​6-​dimethyl-​2-​hepten-​4-​yn-​1-​yl]​-​N-​methyl-1-​naphthalenemethanami​ne

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

작동 메커니즘

Squalene monooxygenase inhibitor

제품 특성

ALogP

5.6

이름과 식별자

이성체 SMILES

CC(C)(C)C#C/C=C/CN(C)CC1=CC=CC2=CC=CC=C21

대체 CAS

91161-71-6

PubChem CID

1549008

MeSH 용어

(E)-N-(6,6-dimethyl-2-heptenynyl)-N-methyl-1-naphthalenementhamin hydrochloride;DA 5505;Lamisil;SF 86 327;SF 86-327;SF 86327;SF-86-327;SF86327;TDT 067;TDT-067;TDT067;terbinafine;terbinafine hydrochloride;Terbinafine, (Z)-;terbinafine, (Z)-isomer

분자량

291.43

관련 대상(인간)

CYP2D6 Tclin Cytochrome P450 2D6 (1 Activities)

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SQLE Tchem Squalene monooxygenase (1 Activities)

Discover Target: SQLE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (2 Activities)

Discover Target: SIGMAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 128 mg/mL (199.49 mM); Water: Insoluble; Ethanol: Insoluble
• 녹는점(°C): 43 °C