TH 1217 - ≥98%(HPLC) , CAS No.1862212-48-3

CAS: 1862212-48-3 Cat. No.: T288726 분자식: C₂₀H₁₇BCl₂N₄O₆ 분자량: 491.09 PubChem CID: 137919863

GRADE & PURITY ≥98%(HPLC)

Synonyms

2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Product description：

TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.

Specifications

동의어

2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

사양 및 순도

≥98%(HPLC)

생화학 및 생리적 메커니즘

Potent dCTPase pyrophosphatase 1 inhibitor (IC50= 47 nM).TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

MODULATOR

순수함

≥98%(HPLC)

이름과 식별자

• Pubchem Sid: 528767393
• 정식 스마일: CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl
• InChIKey: HWFRCQHNILGMLL-UHFFFAOYSA-N
• PubChem CID: 137919863
• 분자량: 491.09

화학 및 물리적 특성

• 용해성: Solvent:DMSO, Max Conc. mg/mL: 49.11, Max Conc. mM: 100