Thiamet G - Moligand™, ≥99% , Inhibitor of O-GlcNAcase, CAS No.1009816-48-1, Inhibitor of O-GlcNAcase

Name: Thiamet G - Moligand™, ≥99% , Inhibitor of O-GlcNAcase, CAS No.1009816-48-1, Inhibitor of O-GlcNAcase
Brand: Aladdin Scientific
SKU: T129644
Availability: InStock

CAS: 1009816-48-1 Cat. No.: T129644 분자식: C₉H₁₆N₂O₄S 분자량: 248.3 EC 번호: 802-306-7 PubChem CID: 135566354

COA

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Thiamet G - Moligand™, ≥99% CAS No(1009816-48-1) by Aladdin Scientific

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주문 가능

등급 & 순도 Moligand™ ? ≥99%

Synonyms

(3aR,5R,6S,7R,7aR)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요 사양 이름과 식별자 문서 고급 데이터 Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 솔루션 계산기 리뷰

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이 등급을 선택하는 이유

Moligand™, ≥99% Moligand™ 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.

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보관 및 배송

Store at -20°C Ice chest + Ice pads 출고. 정확한 사양은 로트별 COA를 확인하세요.

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품질 문서

SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.

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문헌적 근거

크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 0편에서 인용되었습니다.

개요

Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.

Application：

Thiamet G has been used as an O-GlcNAcase inhibitor:

to treat human embryonic kidney 293 cells in order to study its effect on Wnt/beta-catenin signalling

to treat lytically-replicating producer

to incubate mice (C57BL/6) aortic segments to increase global O-GlcNAc levels

사양

동의어

(3aR,5R,6S,7R,7aR)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol

사양 및 순도

Moligand™, ≥99%

생화학 및 생리적 메커니즘

Potent, selective O-GlcNAcase inhibitor (K i = 21 nM). Blocks tau phosphorylation. Increases O-GlcNAc-modified protein levels (EC 50 = 30 nM). Shows antitauopathic effects in vivo . Orally active. Blood-brain barrier permeable.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of O-GlcNAcase

참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥99%

이름과 식별자

Pubchem Sid

504773396

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773396

정식 스마일

CCN=C1NC2C(C(C(OC2S1)CO)O)O

IUPAC Name

(3aR,5R,6S,7R,7aR)-2-ethylimino-5-(hydroxymethyl)-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-6,7-diol

InChIKey

PPAIMZHKIXDJRN-FMDGEEDCSA-N

INCHI

1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1

이성체 SMILES

CCN=C1N[C@@H]2[C@H]([C@@H]([C@H](O[C@@H]2S1)CO)O)O

WGK 독일

PubChem CID

135566354

분자량

248.3

문서

📋 안전 데이터 시트(SDS)

위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.

<<<<<<< HEAD SDS 다운로드 → ======= SDS 다운로드 → >>>>>>> release248-p3

✅ 분석 성적서(COA)

로트별 품질 데이터. 로트 번호를 입력하여 정확한 COA를 확인하세요.

COA 조회 →

📊 데이터시트

제품 사양 및 응용 분야에 대한 빠른 참조 요약.

데이터시트 보기 →

🔬 사양서

이 등급의 전체 품질 특성 및 합격 기준.

사양서 보기 →

고급 데이터

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - 분류 Organooxygen compounds
    - Subclass Carbohydrates and carbohydrate conjugates

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
분류	Organooxygen compounds
Subclass	Carbohydrates and carbohydrate conjugates
Intermediate Tree Nodes	Not available
Direct Parent	Monosaccharides
Alternative Parents	Oxanes Thiazolines Monothioacetals Secondary alcohols Isothioureas 1,2-diols Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Carboximidamides Azacyclic compounds Primary alcohols Hydrocarbon derivatives Amines
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Monosaccharide - Oxane - Monothioacetal - Meta-thiazoline - 1,2-diol - Isothiourea - Secondary alcohol - Carboximidamide - Azacycle - Oxacycle - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Primary alcohol - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Alcohol - Amine - Aliphatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as monosaccharides. These are compounds containing one carbohydrate unit not glycosidically linked to another such unit, and no set of two or more glycosidically linked carbohydrate units. Monosaccharides have the general formula CnH2nOn.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D 구조

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리뷰

등급 선택에 도움이 필요하신가요?

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Moligand™ 등급 가이드 보기 →

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Lot Number	Certificate Type	날짜	항목
I2621172	Certificate of Analysis	Sep 28, 2026	T129644
C23071220	Certificate of Analysis	Sep 01, 2026	T129644
C23071222	Certificate of Analysis	Sep 01, 2026	T129644
C23071228	Certificate of Analysis	Sep 01, 2026	T129644
C23071236	Certificate of Analysis	Sep 01, 2026	T129644
C23071239	Certificate of Analysis	Sep 01, 2026	T129644
J2429118	Certificate of Analysis	Aug 04, 2026	T129644
E2609069	Certificate of Analysis	May 19, 2026	T129644

용해성	DMSO 50 mg/mL Water 50 mg/mL Ethanol 12 mg/mL
특정 회전[α]	α]/D -21 to -26°, c = 0.3 in methanol
분자량	248.300 g/mol
XLogP3	-0.700
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	248.083 Da
Monoisotopic Mass	248.083 Da
Topological Polar Surface Area	120.000 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	289.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1