티오스트렙톤 - ≥98% 이상, 스트렙토마이세스 로렌티에서 추출한 것 , CAS No.1393-48-2

Name: 티오스트렙톤 - ≥98% 이상, 스트렙토마이세스 로렌티에서 추출한 것 , CAS No.1393-48-2
SKU: T102394
Availability: InStock

CAS: 1393-48-2 Cat. No.: T102394 분자식: C₇₂H₈₅N₁₉O₁₈S₅ 분자량: 1664.89 EC 번호: 215-734-9

3 Citations COA

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티오스트렙톤 - ≥98% 이상, 스트렙토마이세스 로렌티에서 추출한 것 CAS No(1393-48-2) by Aladdin Scientific

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주문 가능

GRADE & PURITY ≥98% from Streptomyces laurentii

Synonyms

Storage

빛으로부터 보호, -20°C에서 건조 보관

Shipped In

아이스 박스 + 아이스 패드

개요 Specifications 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 자주 묻는 질문과 기사 Citations of This Product 참고 문헌 솔루션 계산기 리뷰 자주 묻는 질문

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Why this grade

≥98% 이상, 스트렙토마이세스 로렌티에서 추출한 것 for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

빛으로부터 보호, -20°C에서 건조 보관 Ships 아이스 박스 + 아이스 패드 Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

티오스트렙톤은 티아졸과 기타 구조적으로 흥미로운 모티브로 조밀하게 구성된 사이클릭 펩타이드 항생제입니다. 티오스트렙톤은 단백질 합성의 신장 단계 이후 리보솜 회전율을 차단하여 리보솜에서 신장 인자 G(EF-G)의 해리와 GTP 가수분해 후 EF-G에서 무기 인산염의 방출을 모두 억제함으로써 항생제 활성을 나타냅니다. 티오스트렙톤은 또한 많은 악성 종양에서 일반적으로 과발현되는 포크헤드 박스 M1(FOXM1) 전사인자의 하향 조절을 통해 암세포 성장에 대한 효능을 보이는 것으로 설명됩니다. 티오스트렙토는 FOXM1의 억제제입니다
단백질 합성 억제 항생제입니다

Specifications

동의어

사양 및 순도

≥98% 이상, 스트렙토마이세스 로렌티에서 추출한 것

생화학 및 생리적 메커니즘

신장 인자 G (EF-G)와 GTP가 50S 리보솜 서브 유닛에 결합하는 것을 방지하는 펩타이드 항생제.강력한 그람 양성 항생제. 단백질 합성 억제제. FOXM1을 억제합니다. 생체 내에서 항종양 효과를 나타냅니다. 시스플라틴(Asc 1398)을 강화합니다

보관 조건

빛으로부터 보호, -20°C에서 건조 보관

배송

아이스 박스 + 아이스 패드

참고

가능하면 당일에 용액을 준비하여 사용하는 것이 좋습니다. 그러나 미리 원액을 만들어야 하는 경우에는 -20°C에서 단단히 밀봉된 바이알에 소량씩 보관하는 것이 좋습니다. 일반적으로 최대 1주일 동안 사용할 수 있습니다. 사용하기 전에 바이알을 열기 전에 제품을 실온에서 최소 1시간 동안 평형을 이루도록 하는 것이 좋습니다. 용해도, 사용법 및 취급에 대한 추가 정보가 필요하신가요? 자주 묻는 질문(FAQ) 페이지에서 자세한 내용을 확인하세요.

순수함

≥98%

이름과 식별자

Pubchem Sid	504768412
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768412
정식 스마일	CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
IUPAC Name	N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(11Z)-37-butan-2-yl-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide
InChIKey	NSFFHOGKXHRQEW-BXVAPQLOSA-N
INCHI	1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-
이성체 SMILES	CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C/C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
WGK 독일	3
RTECS	XN6300100
분자량	1664.89
Reaxy-Rn	24868543
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24868543&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - 분류 Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Peptides
        Level6 Cyclic peptides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
분류	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Peptides
Direct Parent	Cyclic peptides
Alternative Parents	Pyridinecarboxylic acids Tetrahydropyridines 2,4-disubstituted thiazoles Aralkylamines Imidothiolactones Thiazolines Tertiary alcohols Cyclic carboximidic acids Heteroaromatic compounds Secondary alcohols Amino acids and derivatives Carboxylic acid esters Ketimines Lactones Dialkylamines Polyols Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Organic oxides Aromatic alcohols
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Cyclic alpha peptide - Pyridine carboxylic acid - 2,4-disubstituted 1,3-thiazole - Tetrahydropyridine - Aralkylamine - Pyridine - Imidothiolactone - Azole - Tertiary alcohol - Heteroaromatic compound - Thiazole - Meta-thiazoline - Cyclic carboximidic acid - Carboxylic acid ester - Ketimine - Lactone - Secondary alcohol - Amino acid or derivatives - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidic acid - Carboximidic acid derivative - Azacycle - Secondary aliphatic amine - Organoheterocyclic compound - Oxacycle - Polyol - Secondary amine - Imine - Aromatic alcohol - Amine - Organonitrogen compound - Organooxygen compound - Alcohol - Organic oxide - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as cyclic peptides. These are compounds containing a cyclic moiety bearing a peptide backbone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

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리뷰

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1393-48-2, the molecular formula is C72H85N19O18S5, and the molecular weight is 1664.89 g/mol. InChIKey NSFFHOGKXHRQEW-BXVAPQLOSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

📚 Citations by Application

Organic synthesis — reaction medium1

Drug / compound screening1

Cell proliferation2

Cell viability2

Cytotoxicity screening2

Other applications1

View all 3 citations →

Bulk & Custom Packaging Need larger quantities or custom specifications? Contact our team for a tailored quote.

Lot Number	Certificate Type	날짜	항목
L2103291	Certificate of Analysis	Sep 09, 2025	T102394
G2209391	Certificate of Analysis	Jun 18, 2022	T102394
I2403008	Certificate of Analysis	Jun 18, 2022	T102394
G2209389	Certificate of Analysis	Jun 18, 2022	T102394

용해성	Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic acid, and DMF. Insoluble in water
감도	Light sensitive;Moisture sensitive
녹는점(°C)	246-256°C
분자량	1664.900 g/mol
XLogP3	0.600
Hydrogen Bond Donor Count	17
Hydrogen Bond Acceptor Count	31
Rotatable Bond Count	12
Exact Mass	1663.49 Da
Monoisotopic Mass	1663.49 Da
Topological Polar Surface Area	701.000 Å²
Heavy Atom Count	114
Formal Charge	0
Complexity	3940.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	17
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1