TMP195 - 10mM in DMSO , CAS No.1314891-22-9

CAS: 1314891-22-9 Cat. No.: T408048 분자식: C₂₃H₁₉F₃N₄O₃ 분자량: 456.42 PubChem CID: 67324851

GRADE & PURITY 10mM in DMSO

Synonyms

TFMO 2 | Benzamide, N-​[2-​methyl-​2-​(2-​phenyl-​4-​oxazolyl)​propyl]​-​3-​[5-​(trifluoromethyl)​-​1,​2,​4-​oxadiazol-​3-​yl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

TMP195 TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.
In vitro

TMP195 has low potency in recombinant class I and IIb HDAC assays, enabling full inhibition of class IIa HDAC activity without inhibition of other HDACs. TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures and significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle (DMSO)-treated M-CSF plus GM-CSF cultures. TMP195 influences human monocyte responses to the colony-stimulating factors CSF-1 and CSF-2 in vitro.

In vivo

In vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours. TMP195 treatment significantly decreases proliferating tumour cells, most notably at the leading edge of the tumour. The anti-tumour macrophage phenotype induced by TMP195 treatment thus enhances the efficacy and durability of both standard chemotherapeutic regimens and checkpoint blockade immunotherapy in this mouse model of breast cancer.
Cell Data

cell lines：

Concentrations：300 nM

Incubation Time：5 days

Powder Purity:≥98%

Specifications

동의어

TFMO 2 | Benzamide, N-​[2-​methyl-​2-​(2-​phenyl-​4-​oxazolyl)​propyl]​-​3-​[5-​(trifluoromethyl)​-​1,​2,​4-​oxadiazol-​3-​yl]​-

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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제품 특성

• ALogP: 4.525
• HBD 수: 1
• 회전 가능한 결합: 7

이름과 식별자

• 이성체 SMILES: CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4
• PubChem CID: 67324851
• 분자량: 456.42

관련 대상(인간)

HDAC4 Tclin Histone deacetylase 4 (1 Activities)

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 (1 Activities)

Discover Target: HDAC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 (1 Activities)

Discover Target: HDAC9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 (1 Activities)

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro Water: 24 mg/mL (9.17 mM)
• DMSO(mg/mL) 최대 용해도: 91
• DMSO(mM) 최대 용해도: 199.3777661
• 물(mg/mL) 최대 용해도: ＜1

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1314891-22-9, the molecular formula is C23H19F3N4O3, and the molecular weight is 456.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.