Determine the necessary mass, volume, or concentration for preparing a solution.
Why this grade
Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy
In Vitro（for reference only）
TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG).
Cell Viability Assay
Cell Line: U-87 MG cells
Concentration: 10 μg/ml
Incubation Time: 24 hours
Result: Decreased the total number of ROS-positive cells and showed no toxic effects to U-87 MG cells.
In Vivo（for reference only）
TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides.
Animal Model: Male CD rats
Dosage: 0.1, 0.32, 1.0, 3.2 and 10 mg/kg
Administration: Subcutaneous injection; 0.1-10 mg/kg once
Result: Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.
Form:Solid
IC50& Target:IC50: 0.8 nM (PDE10A), 31.72 μg/mL (DPPH), 16.04 μg/mL (CUPRAC)
Specifications
동의어
TP-10
사양 및 순도
Moligand™, ≥99%
생화학 및 생리적 메커니즘
TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy.
보관 조건
Store at -20°C
배송
Ice chest + Ice pads
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등급
Moligand™
작업 유형
INHIBITOR
순수함
≥99%
이름과 식별자
| 분자량 | 460.45 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
화학 및 물리적 특성
| 용해성 | DMSO : 100 mg/mL (217.18 mM; Need ultrasonic) |
|---|
솔루션 계산기
리뷰
고객 리뷰
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View Moligand™ grade guide →Remind me later
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