TP0472993 - 10mM in DMSO , CAS No.2126874-77-7

CAS: 2126874-77-7 Cat. No.: T656160 분자식: C₁₆H₂₀N₄O₂ 분자량: 300.36

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2 , with IC 50 s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases

In Vitro

CYP4A11/CYP4F2-IN-2 (compound 11c) inhibits 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC 50 of 29 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CYP4A11/CYP4F2-IN-2 (compound 11c) (0.03-1 mg/kg; a single p.o.) inhibits renal 20-HETE production of rats in a dose-dependent manner . CYP4A11/CYP4F2-IN-2 (0.5 mg/kg; i.v.) exhibits low CL (1430 mL/h/kg), moderate V dss (763 mL/kg), and short T 1/2 (0.424 h) in mice . CYP4A11/CYP4F2-IN-2 (1 mg/kg; i.v.) exhibits low CL (226 mL/h/kg), moderate V dss (839 mL/kg), and T 1/2 (3.01 h) in SD rats . CYP4A11/CYP4F2-IN-2 (1 mg/kg; p.o.) exhibits C max (623 ng/mL), T 1/2 (3.03 h), and high bioavailability (97.7%) in SD rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CYP4A11 140 nM (IC 50 ) CYP4F2 40 nM (IC 50 )

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2 , with IC 50 s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases.

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 분자량: 300.36

자주 묻는 질문

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2126874-77-7, the molecular formula is C16H20N4O2, and the molecular weight is 300.36 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.