10mM in DMSO 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.
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SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.
크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 1편에서 인용되었습니다.
Information
Tyrphostin 9 (SF 6847, RG-50872) is firstly designed as anEGFRinhibitor withIC50of 460 μM, but is also found to be more potent toPDGFRwithIC50of 0.5 μM.
In vitro
SF 6847 inhibits the replication of herpes simplex virus type 1 (HSV-1) with IC50 of 40 nM. SF 6847 (50 nM) partly reverses sodium orthovanadate induced HSV-1 plaque formation. SF 6847 (< 400 nM) decreases the phosphorylation of viral phosphoproteins in a dose-dependent manner, but the SF 6847 (< 800 nM)-induced reduction of protein synthesis is not dose-dependent. SF 6847 prevents PDGF-induced tyrosine phosphorylation of LRP in caveolae in human fibroblasts suggesting that PDGF-BB-mediated LRP activation requires tyrosine phosphorylation and therefore activation of PDGFR-β. SF 6847 (1 mM) blocks the strain-induced stimulatory effect on DNA synthesis of fetal lung cells. SF 6847 (1 μM) causes increased exon inclusion of MAPT exon 10. SF 6847 does not affect the translation or stability of the two mRNAs. SF 6847 (1.6 μM) increases the inclusion of MAPT exon 10 by 2-fold in SHSY-5Y cells.
In vivo
Cell Data
cell lines：A431, BGC-823, A549, H460, HCT8, KB and Bel-7402 cells.
Concentrations：
Incubation Time：
Powder Purity:≥99%
위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 날짜 | 항목 |
|---|---|---|---|
 F2426213 | Certificate of Analysis | May 20, 2026 | T408102 |
| 용해성 | Solubility (25°C) In vitro DMSO: 51 mg/mL (197.46 mM); |
|---|---|
| 굴절률 | 1.56 |
| 끓는점(°C) | ~386.8° C at 760 mmHg |
| 녹는점(°C) | 139-140°C |
