10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Tyrphostin 9 (SF 6847, RG-50872) is firstly designed as anEGFRinhibitor withIC50of 460 μM, but is also found to be more potent toPDGFRwithIC50of 0.5 μM.
In vitro
SF 6847 inhibits the replication of herpes simplex virus type 1 (HSV-1) with IC50 of 40 nM. SF 6847 (50 nM) partly reverses sodium orthovanadate induced HSV-1 plaque formation. SF 6847 (< 400 nM) decreases the phosphorylation of viral phosphoproteins in a dose-dependent manner, but the SF 6847 (< 800 nM)-induced reduction of protein synthesis is not dose-dependent. SF 6847 prevents PDGF-induced tyrosine phosphorylation of LRP in caveolae in human fibroblasts suggesting that PDGF-BB-mediated LRP activation requires tyrosine phosphorylation and therefore activation of PDGFR-β. SF 6847 (1 mM) blocks the strain-induced stimulatory effect on DNA synthesis of fetal lung cells. SF 6847 (1 μM) causes increased exon inclusion of MAPT exon 10. SF 6847 does not affect the translation or stability of the two mRNAs. SF 6847 (1.6 μM) increases the inclusion of MAPT exon 10 by 2-fold in SHSY-5Y cells.
In vivo
Cell Data
cell lines：A431, BGC-823, A549, H460, HCT8, KB and Bel-7402 cells.
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N |
|---|---|
| WGK Germany | 3 |
| RTECS | OO3737000 |
| PubChem CID | 5614 |
| Molecular Weight | 282.38 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2426213 | Certificate of Analysis | May 20, 2026 | T408102 |
| Solubility | Solubility (25°C) In vitro DMSO: 51 mg/mL (197.46 mM); |
|---|---|
| Refractive Index | 1.56 |
| Boil Point(°C) | ~386.8° C at 760 mmHg |
| Melt Point(°C) | 139-140°C |
| 1. Jixin Chen, Guoyou Chen, Yueheng Wu, Shuai Liu, Yifan Ma, Maonan Liu, Wei Yu. (2025) Ciprofol Regulates the Activity of Mitochondrial Respiratory Chain Complex I During Cerebral Ischemia-Reperfusion by Targeting Flavin Mononucleotide: A Metabolomic Study. Journal of Integrative Neuroscience, 24 (8): (40079). [PMID:40919627] [10.31083/JIN40079] |
