UAMC-3203 - 10mM in DMSO , CAS No.2271358-64-4

CAS: 2271358-64-4 Cat. No.: U408498 분자식: C₂₅H₃₇N₅O₂S 분자량: 471.66 PubChem CID: 137701965

등급 & 순도 10mM in DMSO

Synonyms

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
In vitro

UAMC-3203 has an impressive t1/2 when incubated with both human and rat microsomes (t1/2 = 20.5 h and t1/2 = 16.5 h respectively) but is found to be relatively less stable when incubated with murine microsomes (t1/2 = 3.46 h).

In vivo

UAMC-3203 significantly lowers the plasma levels of lactate dehydrogenase (LDH) in mice. It is rapidly removed from the bloodstream and redistributed into various tissues, as can be expected for lipophilic basic compounds. Significant concentrations of UAMC-3203 are found in all analyzed tissues (liver, kidney, and lungs).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

사양

동의어

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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제품 특성

ALogP

3.36

HBD 수

4

회전 가능한 결합

10

이름과 식별자

이성체 SMILES

C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)NCCN3CCNCC3)NCC4=CC=CC=C4

PubChem CID

137701965

분자량

471.66

화학 및 물리적 특성

• DMSO(mg/mL) 최대 용해도: 94
• DMSO(mM) 최대 용해도: 199.296103125133
• 물(mg/mL) 최대 용해도: ＜1