Ulixertinib (BVD-523) - Moligand™, 10mM in DMSO , MAP kinase ERK2 inhibitor, CAS No.869886-67-9, MAP kinase ERK2 inhibitor

CAS: 869886-67-9 Cat. No.: U409233 분자식: C₂₁H₂₂Cl₂N₄O₂ 분자량: 433.33 PubChem CID: 11719003

등급 & 순도 Moligand™, 10mM in DMSO

Synonyms

VRT752271 | 4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Ulixertinib (BVD-523) Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.
In vitro

In an A375 melanoma cell line containing a b-RAFV600E mutation, Ulixertinib reduces the levels of phosphorylated ERK2 (pERK) and of the phosphorylation of the downstream kinase RSK (pRSK) with IC50 of 4.1/0.14 μM, respectively. Ulixertinib also inhibits A375 cell proliferation with IC50 of 180 nM.

In vivo

Cell Data

cell lines：A2780, Calu-3, HL-60, K562, St-4, HT-29, KB-3-1, Capan-1, 4-1St and HCT-15 cells

Concentrations：~30 μM

Incubation Time：72 h

Powder Purity:≥99%

사양

동의어

VRT752271 | 4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

MAP kinase ERK2 inhibitor

제품 특성

ALogP

4.266

HBD 수

4

회전 가능한 결합

7

이름과 식별자

이성체 SMILES

CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)Cl

PubChem CID

11719003

분자량

433.33

관련 대상(인간)

MAPK1 Tchem Mitogen-activated protein kinase 1 (1 Activities)

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK3 Tchem Mitogen-activated protein kinase 3 (1 Activities)

Discover Target: MAPK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• DMSO(mg/mL) 최대 용해도: 86
• DMSO(mM) 최대 용해도: 198.4630651
• 물(mg/mL) 최대 용해도: ＜1

자주 묻는 질문

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 869886-67-9, the molecular formula is C21H22Cl2N4O2, and the molecular weight is 433.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.