V-9302 - 10mM in DMSO , CAS No.1855871-76-9

CAS: 1855871-76-9 Cat. No.: V408037 분자식: C₃₄H₃₈N₂O₄ 분자량: 538.68 PubChem CID: 127035871

GRADE & PURITY 10mM in DMSO

Synonyms

Butanoic acid, 2-​amino-​4-​[bis[[2-​[(3-​methylphenyl)​methoxy]​phenyl]​methyl]​amino]​-​, (2S)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

V-9302 V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V
In vitro

V-9302 inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency (IC50 V-9302 = 9.6 µM) over gamma-L-glutamyl-p-nitroanilide (GPNA; IC50 = 1000 µM).

In vivo

Pharmacological blockade of ASCT2 with V-9302 results in attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress, which collectively, contributes to anti-tumor responses in vitro and in murine models in vivo. The steady-state plasma concentrations are achieved 4 h post-administration, with a half-life of approximately 6 h in healthy mice. Following a single acute V-9302 exposure (4 h), plasma glucose levels are not significantly different than vehicle controls, yet plasma glutamine levels are elevated by approximately 50% in V-9302-treated mice compared to vehicle controls, likely a pharmacodynamic effect. Plasma glucose levels in mice chronically exposed to V-9302 or vehicle over a 21-day regimen are not significantly different, while plasma glutamine levels are slightly decreased.
Cell Data

cell lines：

Concentrations：25 µM

Incubation Time：48 h

Powder Purity:≥99%

Specifications

동의어

Butanoic acid, 2-​amino-​4-​[bis[[2-​[(3-​methylphenyl)​methoxy]​phenyl]​methyl]​amino]​-​, (2S)​-

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blo

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

CC1=CC(=CC=C1)COC2=CC=CC=C2CN(CC[C@@H](C(=O)O)N)CC3=CC=CC=C3OCC4=CC=CC(=C4)C

PubChem CID

127035871

분자량

538.68

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1855871-76-9, the molecular formula is C34H38N2O4, and the molecular weight is 538.68 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.