Vecuronium Bromide - 10mM in DMSO , CAS No.50700-72-6

CAS: 50700-72-6 Cat. No.: V408906 분자식: C₃₄H₅₇N₂O₄.Br 분자량: 637.73 Beilstein Registry Number: 4837308 EC 번호: 256-723-9 PubChem CID: 39764

등급 & 순도 10mM in DMSO

Synonyms

ORG NC45 | Piperidinium, 1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
In vitro

Vecuronium inhibits both forms of the muscle-type acetylcholine receptor with IC50 of 1-2 mM. Vecuronium combined with methylprednisolone shows additive effects on both receptor forms, which is best described by a two-site model, with each site independent. Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.

In vivo

Vecuronium (a monoquaternary ammonium compound) has a higher biliary clearance than pancuronium (a bisquaternary ammonium compound) in the rats.
Cell Data

cell lines：A549, H157, H460, H446, HCT116, HT29, SW480, DLD1, Caco2, LNCap, DU145, MDA468, MDA231, HEK293, and PC3-MM2

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

ORG NC45 | Piperidinium, 1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1N4CCCCC4)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]

WGK 독일

3

RTECS

TN4875000

PubChem CID

39764

분자량

637.73

Beilstein

4837308

Reaxy-Rn

4106207

화학 및 물리적 특성

• 특정 회전[α]: 32° (C=1,0.05mol/L HCl)
• 녹는점(°C): 235 °C(dec.)