Verucerfont - 10mM in DMSO , Corticotropin releasing factor receptor 1 antagonist, CAS No.885220-61-1, Corticotropin releasing factor receptor 1 antagonist

CAS: 885220-61-1 Cat. No.: V654873 분자식: C₂₂H₂₆N₆O₂ 분자량: 406.48 EC 번호: 629-872-6 PubChem CID: 11596613

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Verucerfont is a corticotropin-releasing factor receptor 1 ( CRF1 ) antagonist with IC 50 s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.

In Vivo

Post hoc analysis shows that the prototypic non-peptide CRF1 receptor antagonist NBI30775 (R121919) and Verucerfont are both significantly different from vehicle, CP-316 311, and pexacerfont (P<0.001 for all comparisons collapse across time-points); the latter three treatments in turn do not differ from each other. A differential effect of treatments over time is also shown by a significant treatment×time interaction (F[20,140]=6.4, P<0.001). Accordingly, detailed Post hoc analysis shows that both NBI30775 and Verucerfont inhibit ACTH release throughout the following 6 h of measurement (P<0.001 vs vehicle at each time-point, and vs the respective pretreatment baseline) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 6.1 nM (CRF1), >1000 nM (CRF2), >1000 nM (CRF-BP)

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Verucerfont is a corticotropin-releasing factor receptor 1 ( CRF1 ) antagonist with IC 50 s of ~6.1, >1000 and >1000u2009nM for CRF1, CRF2, and CRF-BP, respectively.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

ANTAGONIST

작동 메커니즘

Corticotropin releasing factor receptor 1 antagonist

제품 특성

ALogP

4.5

이름과 식별자

이성체 SMILES

CC[C@@H](C1=NC(=NO1)C)NC2=CC(=NC3=C(C(=NN23)C)C4=C(C=C(C=C4)OC)C)C

PubChem CID

11596613

분자량

406.48