VU 0364439 - 10mM in DMSO , CAS No.1246086-78-1

CAS: 1246086-78-1 Cat. No.: V408515 분자식: C₁₈H₁₃Cl₂N₃O₃S 분자량: 422.29 PubChem CID: 46934289

등급 & 순도 10mM in DMSO

Synonyms

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

VU 0364439 is amGlu4positive allosteric modulator (PAM), withEC50of 19.8 nM.
In vitro

In vivo

VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
Cell Data

cell lines：HeLa, HCT116, HT29, LOVO, DU145, and NHDF cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl

PubChem CID

46934289

분자량

422.29

관련 대상(인간)

GRM4 Tchem Metabotropic glutamate receptor 4 (4 Activities)

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.69 mM); Ethanol: 58 mg/mL (199.69 mM); Water: Insoluble