VU6000918 - ≥99% , CAS No.2101737-32-8

CAS: 2101737-32-8 Cat. No.: V646544 분자식: C₁₈H₁₇F₂N₅OS 분자량: 389.42

등급 & 순도 ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC 50 of 19 nM for hM4

In Vitro

VU6000918 demonstrates statistically significant AHL reversal (18%) from a low oral dose of 0.03 mg/kg and reaches maximal reversal (74%) from a 3 mg/kg dose, with a resulting in vivo plasma EC 50 of 74 nM (0.66 nM unbound) based on terminal concentrations measured in the study animals (1.5 hr post-administration of 17j). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 19 nM (hM4)

사양

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC 50 of 19 nM for hM4.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥99%

이름과 식별자

정식 스마일

O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NC3CN(C4=CC=CC(F)=C4F)C3

분자량

389.42

화학 및 물리적 특성

• 용해성: DMSO : 125 mg/mL (320.99 mM; Need ultrasonic)