Wiskostatin - ≥98%(HPLC) , CAS No.253449-04-6

CAS: 253449-04-6 Cat. No.: W169057 분자식: C₁₇H₁₈Br₂N₂O 분자량: 426.15 EC 번호: 686-020-6 PubChem CID: 2775510

GRADE & PURITY ≥98%(HPLC)

Synonyms

AS-75867 | J-503093 | KBioGR_000620 | 3,6-Dibromo-alpha-[(dimethylamino)methyl ]-9H-cabazole-9-ethanol | CBDivE_008357 | Oprea1_105682 | C17H18Br2N2O | MFCD00218393 | Oprea1_198540 | Wiskostatin | KBio3_001099 | NCGC00163493-02 | HY-12534 | NCGC00179231-0

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

Wiskostatin is a cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. The compound acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Wiskostatin also binds to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.

Wiskostatin is a selective inhibitor of actin filament assembly

Specifications

동의어

AS-75867 | J-503093 | KBioGR_000620 | 3,6-Dibromo-alpha-[(dimethylamino)methyl ]-9H-cabazole-9-ethanol | CBDivE_008357 | Oprea1_105682 | C17H18Br2N2O | MFCD00218393 | Oprea1_198540 | Wiskostatin | KBio3_001099 | NCGC00163493-02 | HY-12534 | NCGC00179231-0

사양 및 순도

≥98%(HPLC)

생화학 및 생리적 메커니즘

Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. Wiskostatin inhibits actin-dependent cellular functions, including migration, transm

보관 조건

Store at -20°C,Argon charged

배송

Ice chest + Ice pads

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참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥98%(HPLC)

이름과 식별자

Pubchem Sid

504761908

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504761908

정식 스마일

CN(C)CC(CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O

IUPAC Name

1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol

InChIKey

XUBJEDZHBUPBKL-UHFFFAOYSA-N

INCHI

1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3

이성체 SMILES

CN(C)CC(CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O

WGK 독일

3

PubChem CID

2775510

분자량

426.15

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives
        • Level5 Brominated biphenyls
          • Level6 Polybrominated biphenyls

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Brominated biphenyls
• Direct Parent: Polybrominated biphenyls
• Alternative Parents: Carbazoles N-alkylindoles Indoles Substituted pyrroles Aryl bromides Heteroaromatic compounds Trialkylamines Secondary alcohols 1,2-aminoalcohols Azacyclic compounds Organopnictogen compounds Organobromides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Polybrominated biphenyl - Carbazole - N-alkylindole - Indole - Indole or derivatives - Aryl bromide - Aryl halide - Substituted pyrrole - Heteroaromatic compound - Pyrrole - 1,2-aminoalcohol - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - Azacycle - Organoheterocyclic compound - Organobromide - Organohalogen compound - Alcohol - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organopnictogen compound - Amine - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as polybrominated biphenyls. These are organic aromatic compounds containing a biphenyl moiety, which is substituted at two or more ring positions by a bromine atom.
• External Descriptors: organobromine compound - tertiary amino compound - secondary alcohol - carbazoles

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

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GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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관련 대상(비인간)

Hdac6 Histone deacetylase 6 (222 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Plasmodium falciparum (966862 Activities)

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L6 (7924 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

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HSP90 (947 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO: 10 mg/mL, clear
• 녹는점(°C): 148-150°C
• 분자량: 426.100 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 425.977 Da
• Monoisotopic Mass: 423.979 Da
• Topological Polar Surface Area: 28.400 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 356.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1