X5050 - ≥98% , CAS No.2404756-81-4

CAS: 2404756-81-4 Cat. No.: X651956 분자식: C₁₇H₁₅N₃O₃ 분자량: 309.32 PubChem CID: 146301742

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

In Vitro

X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NSCs. Concentration: 100 µM. Incubation Time: One day. Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform.

In Vivo

X5050 (2 x 2µl of 20 mM) is active in HD pathological context . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-week-old male C57Bl6 mice .2 Dosage: 2 x 2µl of 20 mM in 10% DMSO in water. Administration: Intraventricular injection. Result: Increased BDNF expression. A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.

Form:Solid

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

순수함

≥98%

이름과 식별자

• 정식 스마일: C=CCONC(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=CC=C3O
• IUPAC Name: 2-(2-hydroxyphenyl)-N-prop-2-enoxy-3H-benzimidazole-5-carboxamide
• InChIKey: RGROIKJLROTDCR-UHFFFAOYSA-N
• INCHI: 1S/C17H15N3O3/c1-2-9-23-20-17(22)11-7-8-13-14(10-11)19-16(18-13)12-5-3-4-6-15(12)21/h2-8,10,21H,1,9H2,(H,18,19)(H,20,22)
• PubChem CID: 146301742
• 분자량: 309.32

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (323.29 mM; Need ultrasonic)