YK11 - 10mM in DMSO , CAS No.1370003-76-1

CAS: 1370003-76-1 Cat. No.: Y656702 분자식: C₂₅H₃₄O₆ 분자량: 430.53 PubChem CID: 119058028

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

In Vitro

YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100?nM or 500?nM). YK11 (0.5?μM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5?μM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 μM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Androgen receptor

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 이성체 SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@]24/C(=C\C(=O)OC)/OC(O4)(C)OC)CCC5=CC(=O)CC[C@H]35
• 대체 CAS: 1370003-76-1
• PubChem CID: 119058028
• MeSH 용어: 17,20-((1-methoxyethylidene)bis(oxy))-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester;YK11 cpd
• 분자량: 430.53