YO-01027 - ≥97% , CAS No.209984-56-5

CAS: 209984-56-5 Cat. No.: Y129283 분자식: C₂₆H₂₃F₂N₃O₃ 분자량: 463.48 EC 번호: 803-181-1 PubChem CID: 11454028

GRADE & PURITY ≥97%

Synonyms

Dibenzazepine (Deshydroxy LY 411575) | NCGC00263188-03 | SB47619 | SCHEMBL3046688 | C26H23F2N3O3 | SW219340-1 | EX-A027 | HMS3884B16 | J-013750 | HY-13526 | s2711 | Dibenzazepine (YO-01027) | HY-13526G | MFCD12828734 | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-meth

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

application:

Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.

Specifications

동의어

Dibenzazepine (Deshydroxy LY 411575) | NCGC00263188-03 | SB47619 | SCHEMBL3046688 | C26H23F2N3O3 | SW219340-1 | EX-A027 | HMS3884B16 | J-013750 | HY-13526 | s2711 | Dibenzazepine (YO-01027) | HY-13526G | MFCD12828734 | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-meth

사양 및 순도

≥97%

생화학 및 생리적 메커니즘

Potent gamma secretase inhbitor (IC 50 = 2.6 nM for APPL cleavage; IC 50 = 2.9 nM for Notch cleavage). Inhibits Notch signaling. Neuroprotective, anti-diabetic, anti-fibrotic and cardioprotective in animal models.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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참고

Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥97%

이름과 식별자

Pubchem Sid

504766441

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504766441

정식 스마일

CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

IUPAC Name

(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

InChIKey

QSHGISMANBKLQL-OWJWWREXSA-N

INCHI

1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1

이성체 SMILES

C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

WGK 독일

3

PubChem CID

11454028

분자량

463.48

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 분류 Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 분류: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Dibenzazepines N-acyl-alpha amino acids and derivatives Alpha amino acid amides Alanine and derivatives Phenylacetamides Fluorobenzenes Azepines Aryl fluorides Tertiary carboxylic acid amides Secondary carboxylic acid amides Lactams Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organofluorides Organonitrogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-dipeptide - Dibenzazepine - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alanine or derivatives - Benzazepine - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Phenylacetamide - Halobenzene - Fluorobenzene - Azepine - Aryl fluoride - Monocyclic benzene moiety - Benzenoid - Aryl halide - Tertiary carboxylic acid amide - Lactam - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Organoheterocyclic compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organofluoride - Organohalogen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

APH1A Tbio Gamma-secretase (4915 Activities)

Discover Target: APH1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

관련 대상(비인간)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO 93 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• 분자량: 463.500 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 463.171 Da
• Monoisotopic Mass: 463.171 Da
• Topological Polar Surface Area: 78.500 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 756.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 209984-56-5, the molecular formula is C26H23F2N3O3, and the molecular weight is 463.48 g/mol. InChIKey QSHGISMANBKLQL-OWJWWREXSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.