CDK

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  1. Ro 3306, Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5
    CAS: 872573-93-8 Formula: C18H13N3OS2 Molecular Weight: 351.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: R275210
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    IUPAC Name
    (5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylimino)-1,3-thiazolidin-4-one
    SMILES
    C1=CC2=C(C=CC(=C2)C=C3C(=O)NC(=NCC4=CC=CS4)S3)N=C1
    InChIKey
    XOLMRFUGOINFDQ-YBEGLDIGSA-N
    InChI
    1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
    Synonyms
    (5Z)-5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino)-4(5H)-thiazolone
  2. Ryuvidine, Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 4;Inhibitor of lysine methyltransferase 5A
    CAS: 265312-55-8 PubChem CID: 481747 Formula: C15H12N2O2S Molecular Weight: 284.33
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: R275642
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    IUPAC Name
    2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
    SMILES
    CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C
    InChIKey
    HFPLHASLIOXVGS-UHFFFAOYSA-N
    InChI
    1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
    Synonyms
    Cdk4 Inhibitor III | 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole | Ryuvidine
  3. SC 221409
    CAS: 222035-13-4 PubChem CID: 3551941 Formula: C14H11BrN4O3S Molecular Weight: 395.23
    ◐ .Made to order · 8–12 wks Item #: S275762
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    IUPAC Name
    4-[(5-bromo-2-hydroxy-1H-indol-3-yl)diazenyl]benzenesulfonamide
    SMILES
    C1=CC(=CC=C1N=NC2=C(NC3=C2C=C(C=C3)Br)O)S(=O)(=O)N
    InChIKey
    IWDDMLCHUYBHHD-UHFFFAOYSA-N
    InChI
    1S/C14H11BrN4O3S/c15-8-1-6-12-11(7-8)13(14(20)17-12)19-18-9-2-4-10(5-3-9)23(16,21)22/h1-7,17,20H,(H2,16,21,22)
    Synonyms
    4-[2-(5-Bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]benzenesulfonamide
  4. SB 218078, Inhibitor of checkpoint kinase 1
    CAS: 135897-06-2 PubChem CID: 3387354 Formula: C24H15N3O3 Molecular Weight: 393.39
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ◐ .Made to order · 8–12 wks Item #: S287033
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    IUPAC Name
    28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-3,5-dione
    SMILES
    C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
    InChIKey
    OTPNDVKVEAIXTI-UHFFFAOYSA-N
    InChI
    1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29show more
    Synonyms
    EX-A4201 | HMS3229O08 | J-006782 | AKOS024457167 | S6U3J3UP11 | NCGC00167774-01 | SB218078 | SB-218078 | (15S,18R)-28...
  5. Olomoucine II
    CAS: 500735-47-7 Formula: C19H26N6O2 Molecular Weight: 370.45
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: O276007
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    IUPAC Name
    2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-ylpurin-6-yl]amino]methyl]phenol
    SMILES
    CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3O
    InChIKey
    NDUVSANREQEDRE-UHFFFAOYSA-N
    InChI
    1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)
    Synonyms
    2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-ylpurin-6-yl]amino]methyl]phenol | 2-[[[2-(1-hydroxybutan-2-ylamino)-9-p...
  6. PD0332991 HCl
    CAS: 827022-32-2 Formula: C24H29N7O2·HCl Molecular Weight: 483.99
    ● In Stock — US warehouse, ships to EU* Item #: E129959
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    IUPAC Name
    6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride
    SMILES
    CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
    InChIKey
    STEQOHNDWONVIF-UHFFFAOYSA-N
    InChI
    1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-1show more
    Synonyms
    FT-0700370 | Palbociclib (hydrochloride) | PD-0332991 hydrochloride | AKOS000120736 | Pyrido(2,3-d)pyrimidin-7(8H)-on...
  7. NU 2058
    CAS: 161058-83-9 EC Number: 633-908-6 Formula: C12H17N5O Molecular Weight: 247.3
    ● In Stock — US warehouse, ships to EU* Item #: N159684
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    IUPAC Name
    6-(cyclohexylmethoxy)-7H-purin-2-amine
    SMILES
    C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)N
    InChIKey
    MWGXGTJJAOZBNW-UHFFFAOYSA-N
    InChI
    1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17)
    Synonyms
    CCG-222242 | O(6)-cyclohexylmethylguanine | O-Cyclohexylmethylguanine | Tox21_500938 | SMR000568417 | 6-Cyclohexylmet...
  8. PHA-848125, Nerve growth factor receptor Trk-A inhibitor
    CAS: 802539-81-7 Formula: C25H32N8O Molecular Weight: 460.57
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P127815
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    IUPAC Name
    N,1,4,4-tetramethyl-8-[4-(4-methylpiperazin-1-yl)anilino]-5H-pyrazolo[4,3-h]quinazoline-3-carboxamide
    SMILES
    CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C
    InChIKey
    RXZMYLDMFYNEIM-UHFFFAOYSA-N
    InChI
    1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26show more
    Synonyms
    DS-17315 | MMV676602 | SY034854 | NCGC00346673-01 | AC-35945 | AKOS030231455 | Milciclib; PHA 848125 | N,1,4,4-tetram...
  9. P276-00
    CAS: 920113-03-7 Formula: C21H20ClNO5.HCl Molecular Weight: 438.3
    ● In Stock — US warehouse, ships to EU* Item #: P129988
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    IUPAC Name
    2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one;hydrochloride
    SMILES
    CN1CCC(C1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
    InChIKey
    OOVTUOCTLAERQD-OJMBIDBESA-N
    InChI
    1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12-show more
    Synonyms
    A903150 | D72431 | EX-A2121 | P276 | AS-78319 | DRP53ZDY6H | P-27600;2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(h...
  10. PHA-767491, Inhibitor of MAPK activated protein kinase 2;Inhibitor of ribosomal protein S6 kinase A4
    CAS: 845714-00-3 Formula: C12H11N3O Molecular Weight: 213.24
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P127009
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    IUPAC Name
    2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
    SMILES
    C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3
    InChIKey
    DKXHSOUZPMHNIZ-UHFFFAOYSA-N
    InChI
    1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
    Synonyms
    2-(4-pyridyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | BDBM27344 | SMR004702829 | CAY10572(PHA-767491) | CHEBI...
  11. PF-477736, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2
    CAS: 952021-60-2 Formula: C22H25N7O2 Molecular Weight: 419.48
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: P120184
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    IUPAC Name
    (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-6-yl]acetamide
    SMILES
    CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(C5CCCCC5)N)N2
    InChIKey
    NDEXUOWTGYUVGA-LJQANCHMSA-N
    InChI
    1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(show more
    Synonyms
    (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0,4,13]trideca-1,4(13),5...
  12. CKI-7 dihydrochloride
    CAS: 1177141-67-1 EC Number: 689-633-7 PubChem CID: 16078955 Formula: C11H12ClN3O2S · 2HCl Molecular Weight: 358.67
    Solid ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: N134264
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    IUPAC Name
    N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide;dihydrochloride
    SMILES
    C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl.Cl.Cl
    InChIKey
    JUAVTXYOCISSSL-UHFFFAOYSA-N
    InChI
    1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
    Synonyms
    N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide;dihydrochloride | N-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONA...
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Frequently Asked Questions

What can I find under CDK?
This listing collects compounds associated with CDK within our Cell Cycle/DNA Damage area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for CDK?
Consider the reported potency of each CDK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for CDK compounds?
Each CDK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search CDK compounds by activity or structure?
Yes. Filter the CDK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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