CRAC Channel

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  1. GSK-5498A
    CAS: 1253186-49-0 PubChem CID: 46945384 Formula: C18H11F6N3O Molecular Weight: 399.29
    ◐ .Made to order · 8–12 wks Item #: G649231
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    IUPAC Name
    2,6-difluoro-N-[1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide
    SMILES
    C1=CC(=C(C(=C1)F)CN2C=CC(=N2)NC(=O)C3=C(C=CC=C3F)F)C(F)(F)F
    InChIKey
    AUBGZAJDHUHMAE-UHFFFAOYSA-N
    InChI
    1S/C18H11F6N3O/c19-12-4-1-3-11(18(22,23)24)10(12)9-27-8-7-15(26-27)25-17(28)16-13(20)5-2-6-14(16)21/h1-8H,9H2,(H,25,26,28)
  2. Synta66
    CAS: 835904-51-3 PubChem CID: 11337104 Formula: C20H17FN2O3 Molecular Weight: 352.36
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Made to order · 8–12 wks Item #: S649444
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    IUPAC Name
    N-[4-(2,5-dimethoxyphenyl)phenyl]-3-fluoropyridine-4-carboxamide
    SMILES
    COC1=CC(=C(C=C1)OC)C2=CC=C(C=C2)NC(=O)C3=C(C=NC=C3)F
    InChIKey
    GFEIWXNLDKUWIK-UHFFFAOYSA-N
    InChI
    1S/C20H17FN2O3/c1-25-15-7-8-19(26-2)17(11-15)13-3-5-14(6-4-13)23-20(24)16-9-10-22-12-18(16)21/h3-12H,1-2H3,(H,23,24)
  3. 5J-4
    CAS: 827001-82-1 PubChem CID: 2968289 Formula: C16H12N2O3S Molecular Weight: 312.34
    ◐ .Made to order · 8–12 wks Item #: J646772
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    IUPAC Name
    N-[(6-hydroxynaphthalen-1-yl)carbamothioyl]furan-2-carboxamide
    SMILES
    C1=CC2=C(C=CC(=C2)O)C(=C1)NC(=S)NC(=O)C3=CC=CO3
    InChIKey
    WMUSJLJASFXGHN-UHFFFAOYSA-N
    InChI
    1S/C16H12N2O3S/c19-11-6-7-12-10(9-11)3-1-4-13(12)17-16(22)18-15(20)14-5-2-8-21-14/h1-9,19H,(H2,17,18,20,22)
  4. RO2959 monohydrochloride
    CAS: 2309172-44-7 PubChem CID: 45274292 Formula: C21H20ClF2N5OS Molecular Weight: 463.93
    ◐ .Made to order · 8–12 wks Item #: R648159
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    IUPAC Name
    2,6-difluoro-N-[5-[4-methyl-1-(5-methyl-1,3-thiazol-2-yl)-3,6-dihydro-2H-pyridin-5-yl]pyrazin-2-yl]benzamide;hydrochloride
    SMILES
    CC1=C(CN(CC1)C2=NC=C(S2)C)C3=CN=C(C=N3)NC(=O)C4=C(C=CC=C4F)F.Cl
    InChIKey
    GMLSDODALBRLPE-UHFFFAOYSA-N
    InChI
    1S/C21H19F2N5OS.ClH/c1-12-6-7-28(21-26-8-13(2)30-21)11-14(12)17-9-25-18(10-24-17)27-20(29)19-15(22)4-3-5-16(19)23;/h3-5,8-10H,6-7,11H2,1-2H3,(H,25,27,show more
  5. GSK-5503A
    CAS: 1253186-46-7 PubChem CID: 46944784
    ◐ .Made to order · 8–12 wks Item #: G1437906
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    IUPAC Name
    2,6-difluoro-N-[1-[(2-phenoxyphenyl)methyl]pyrazol-3-yl]benzamide
    SMILES
    C1=CC=C(C=C1)OC2=CC=CC=C2CN3C=CC(=N3)NC(=O)C4=C(C=CC=C4F)F
    InChIKey
    FFTYDCLYIJBUCD-UHFFFAOYSA-N
    InChI
    1S/C23H17F2N3O2/c24-18-10-6-11-19(25)22(18)23(29)26-21-13-14-28(27-21)15-16-7-4-5-12-20(16)30-17-8-2-1-3-9-17/h1-14H,15H2,(H,26,27,29)
  6. CRAC intermediate 2
    CAS: 123066-64-8 Formula: C11H7F6N3 Molecular Weight: 295.2
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: C1498972
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  7. MRS1845
    CAS: 544478-19-5 Formula: C21H22N2O6 Molecular Weight: 398.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: M1493643
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  8. RO2959 monohydrochloride
    CAS: 2309172-44-7 PubChem CID: 45274292 Formula: C21H20ClF2N5OS Molecular Weight: 463.93
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: R1494795
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

How is the CRAC Channel listing put together?
It draws on reported CRAC Channel annotations within Membrane Transporter/Ion Channel and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a CRAC Channel modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the CRAC Channel entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for CRAC Channel compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For CRAC Channel work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the CRAC Channel compound I need is not listed?
Search by CAS number or SMILES first, since analogs of CRAC Channel compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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