CRFR

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  1. α-helical CRF 9-41
    CAS: 90880-23-2 PubChem CID: 44593730 Formula: C166H274N46O53S2 Molecular Weight: 3826.40
    ● In Stock — US warehouse, ships to EU* Item #: H287574
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    SMILES
    [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(Cshow more
    InChIKey
    PNGVJHODDQMQKT-GVKLFNHCSA-N
    Synonyms
    α-helical-Corticotropin-Releasing Factor 9-41
  2. CP 376395 hydrochloride
    CAS: 1013933-37-3 Formula: C21H30N2O•HCl Molecular Weight: 362.94
    ◐ .Made to order · 8–12 wks Item #: C287406
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    IUPAC Name
    3,6-dimethyl-N-pentan-3-yl-2-(2,4,6-trimethylphenoxy)pyridin-4-amine;hydrochloride
    SMILES
    CCC(CC)NC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C.Cl
    InChIKey
    UDIOZDHQQNYISB-UHFFFAOYSA-N
    InChI
    1S/C21H30N2O.ClH/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5;/h10-12,18H,8-9H2,1-7H3,(H,22,23);1H
    Synonyms
    N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride | CP 376395 HYDROCHLORIDE | 3,...
  3. CP376395, Antagonist of CRF 1 receptor
    CAS: 175140-00-8 Formula: C21H30N2O Molecular Weight: 326.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C412543
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    IUPAC Name
    3,6-dimethyl-N-pentan-3-yl-2-(2,4,6-trimethylphenoxy)pyridin-4-amine
    SMILES
    CCC(CC)NC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C
    InChIKey
    VIZBSVDBNLAVAW-UHFFFAOYSA-N
    InChI
    1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)
    Synonyms
    VIZBSVDBNLAVAW-UHFFFAOYSA-N | BDBM20966 | 5113G7FP34 | UNII-5113G7FP34 | compound 3a [PMID: 18288792] | GTPL3496 | 3,...
  4. Corticotropin Releasing Factor bovine
    CAS: 92307-52-3 PubChem CID: 71581479 Formula: C206H340N60O63S Molecular Weight: 4697.33
    ● In Stock — US warehouse, ships to EU* Item #: C118797
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    IUPAC Name
    (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[1-[[(2S,3R)-1-[[(2S)-6-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-5-aminshow more
    SMILES
    CCC(C)C(C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CNC=N2)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)Cshow more
    InChIKey
    BMUPKVLWWGQTIL-SFYWBPHXSA-N
    InChI
    1S/C206H340N60O63S/c1-30-104(21)160(199(324)227-106(23)164(216)289)261-195(320)143(88-158(287)288)256-185(310)132(77-99(11)12)248-183(308)130(75-97(7)show more
    Synonyms
    PUBCHEM_71581479 | DTXSID80856168
  5. CRA1000, Antagonist of CRF 1 receptor
    CAS: 226948-11-4 PubChem CID: 9849313
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: C609597
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    IUPAC Name
    N-ethyl-4-[4-(3-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-6-methyl-N-(2-methylsulfanyl-4-propan-2-ylphenyl)pyrimidin-2-amine
    SMILES
    CCN(c1ccc(cc1SC)C(C)C)c1nc(cc(n1)C)N1CCC(=CC1)c1cccc(c1)F
    InChIKey
    DDSMCPASYQDKFS-UHFFFAOYSA-N
    InChI
    1S/C28H33FN4S/c1-6-33(25-11-10-22(19(2)3)18-26(25)34-5)28-30-20(4)16-27(31-28)32-14-12-21(13-15-32)23-8-7-9-24(29)17-23/h7-12,16-19H,6,13-15H2,1-5H3
    Synonyms
    Q27076916 | 3899V9A17F | CRA1000 | CRA-1000 | N-ethyl-4-[4-(3-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-6-methyl-N-(...
  6. CP 154,526, Antagonist of CRF 1 receptor
    CAS: 157286-86-7 PubChem CID: 5311055
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: C609564
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    IUPAC Name
    N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[3,2-e]pyrimidin-4-amine
    SMILES
    CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC
    InChIKey
    FHQYJZCJRZHINA-UHFFFAOYSA-N
    InChI
    1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
    Synonyms
    AKOS032946677 | BDBM50058163 | PDSP2_001283 | CP154526 | CP-154526 | N-butyl-N-ethyl-7-mesityl-2,5-dimethyl-7H-pyrrol...
  7. antalarmin, Antagonist of CRF 1 receptor
    CAS: 157284-96-3 PubChem CID: 177990
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: A607663
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    IUPAC Name
    N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[3,2-e]pyrimidin-4-amine
    SMILES
    CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC
    InChIKey
    IXPROWGEHNVJOY-UHFFFAOYSA-N
    InChI
    1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
    Synonyms
    G3DNT7X7YL | Q4770927 | SCHEMBL466243 | DTXSID50166241 | NCI60_039940 | N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trim...
  8. DMP696, Antagonist of CRF 1 receptor
    CAS: 202578-52-7 PubChem CID: 9909468 Formula: C18H21Cl2N5O2 Molecular Weight: 410.30
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: D609929
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    IUPAC Name
    8-(2,4-dichlorophenyl)-N-(1,3-dimethoxypropan-2-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
    SMILES
    CC1=NN2C(=C1C3=C(C=C(C=C3)Cl)Cl)N=C(N=C2NC(COC)COC)C
    InChIKey
    MDWRPTOUDPFXKK-UHFFFAOYSA-N
    InChI
    1S/C18H21Cl2N5O2/c1-10-16(14-6-5-12(19)7-15(14)20)17-21-11(2)22-18(25(17)24-10)23-13(8-26-3)9-27-4/h5-7,13H,8-9H2,1-4H3,(H,21,22,23)
    Synonyms
    UNII-WCA5SCC429 | MS-27062 | WCA5SCC429 | [8-(2,4-Dichloro-phenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]-(...
  9. NBI-34041, Antagonist of CRF 1 receptor
    CAS: 268545-87-5 PubChem CID: 9888194
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: N612175
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    Technical Identifiers
    SMILES
    CCCC(N1CCn2c3c1cc(C)nc3c(n2)c1ccc(cc1Cl)Cl)CCC
    InChIKey
    AKLMUGFDGONMAA-UHFFFAOYSA-N
    InChI
    1S/C22H26Cl2N4/c1-4-6-16(7-5-2)27-10-11-28-22-19(27)12-14(3)25-21(22)20(26-28)17-9-8-15(23)13-18(17)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3
    Synonyms
    GTPL10375 | NBI 34041 | SCHEMBL16606732 | UNII-874OEY3JEJ | BDBM50171325 | 3-(2,4-Dichlorophenyl)-9-heptan-4-yl-6-met...
  10. Verucerfont, Corticotropin releasing factor receptor 1 antagonist
    CAS: 885220-61-1 EC Number: 629-872-6 PubChem CID: 11596613 Formula: C22H26N6O2 Molecular Weight: 406.48
    ● In Stock — US warehouse, ships to EU* Item #: V647108
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    IUPAC Name
    3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a]pyrimidin-7-amine
    SMILES
    CC[C@@H](C1=NC(=NO1)C)NC2=CC(=NC3=C(C(=NN23)C)C4=C(C=C(C=C4)OC)C)C
    InChIKey
    VKHVAUKFLBBZFJ-SFHVURJKSA-N
    InChI
    1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/s1
    Synonyms
    GSK561679 | 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a]...
  11. Tetracosactide acetate
    CAS: 60189-34-6 PubChem CID: 87126289 Formula: C136H210N40O31S.xC2H4O2 Molecular Weight: 2933.446005
    ◐ .Made to order · 8–12 wks Item #: T650640
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    IUPAC Name
    acetic acid;(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-show more
    SMILES
    CC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=Cshow more
    InChIKey
    XDSGCNRPXJYVQS-GLMYKROOSA-N
    InChI
    1S/C136H210N40O31S.C2H4O2/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142show more
    Synonyms
    Tetracosactrin acetate | SCHEMBL563374
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Frequently Asked Questions

What can I find under CRFR?
This listing collects compounds associated with CRFR within our GPCR/G Protein area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for CRFR?
Consider the reported potency of each CRFR compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for CRFR compounds?
Each CRFR product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search CRFR compounds by activity or structure?
Yes. Filter the CRFR listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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