CRFR

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  1. Emicerfont, Corticotropin releasing factor receptor 1 antagonist
    CAS: 786701-13-1 PubChem CID: 11223423 Formula: C22H24N6O2 Molecular Weight: 404.46
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: E650075
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    IUPAC Name
    1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
    SMILES
    CC1=CC(=C2CCN(C2=N1)C3=C(C=C(C=C3)OC)C)N4C=CC(=N4)N5CCNC5=O
    InChIKey
    JFHJGXQFESYQGY-UHFFFAOYSA-N
    InChI
    1S/C22H24N6O2/c1-14-12-16(30-3)4-5-18(14)26-9-6-17-19(13-15(2)24-21(17)26)28-10-7-20(25-28)27-11-8-23-22(27)29/h4-5,7,10,12-13H,6,8-9,11H2,1-3H3,(H,23show more
    Synonyms
    OJ8EG4264P | A14047 | 1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]...
  2. Mepixanox
    CAS: 17854-59-0 PubChem CID: 65687 Formula: C20H21NO3 Molecular Weight: 323.4
    ◐ .Made to order · 8–12 wks Item #: M694121
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    IUPAC Name
    3-methoxy-4-(piperidin-1-ylmethyl)xanthen-9-one
    SMILES
    COC1=C(C2=C(C=C1)C(=O)C3=CC=CC=C3O2)CN4CCCCC4
    InChIKey
    PYSOHOOUXFWCFF-UHFFFAOYSA-N
    InChI
    1S/C20H21NO3/c1-23-17-10-9-15-19(22)14-7-3-4-8-18(14)24-20(15)16(17)13-21-11-5-2-6-12-21/h3-4,7-10H,2,5-6,11-13H2,1H3
  3. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
    CAS: 150646-45-0 PubChem CID: 131637959
    ◐ .Made to order · 8–12 wks Item #: D1433108
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    IUPAC Name
    (4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2show more
    SMILES
    CCCCC(C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(show more
    InChIKey
    ZRVJFWQRMVCTQT-YWHUVQRVSA-N
    InChI
    1S/C159H267N49O43/c1-24-28-40-94(187-140(236)104(50-57-120(216)217)195-146(242)110(67-81(11)12)202-153(249)123(83(15)16)205-142(238)105(51-58-121(218)show more
  4. BMS-665053
    CAS: 1173435-64-7 PubChem CID: 56671385 Formula: C16H13Cl3F3N3O Molecular Weight: 426.6
    ◐ .Made to order · 8–12 wks Item #: B1433130
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    IUPAC Name
    5-chloro-1-(1-cyclopropylethyl)-3-[2,6-dichloro-4-(trifluoromethyl)anilino]pyrazin-2-one
    SMILES
    CC(C1CC1)N2C=C(N=C(C2=O)NC3=C(C=C(C=C3Cl)C(F)(F)F)Cl)Cl
    InChIKey
    SQKXWTQRMQRCRW-UHFFFAOYSA-N
    InChI
    1S/C16H13Cl3F3N3O/c1-7(8-2-3-8)25-6-12(19)23-14(15(25)26)24-13-10(17)4-9(5-11(13)18)16(20,21)22/h4-8H,2-3H2,1H3,(H,23,24)
  5. CRHR1 antagonist 1
    CAS: 276890-57-4 PubChem CID: 16078985 Formula: C24H35ClN4O Molecular Weight: 431.01
    ◐ .Made to order · 8–12 wks Item #: C1432951
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    IUPAC Name
    4-[ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol;hydrochloride
    SMILES
    CCN(CCCCO)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C.Cl
    InChIKey
    DKVWSJKPRJIFPC-UHFFFAOYSA-N
    InChI
    1S/C24H34N4O.ClH/c1-8-27(11-9-10-12-29)23-21-18(5)19(6)28(24(21)26-20(7)25-23)22-16(3)13-15(2)14-17(22)4;/h13-14,29H,8-12H2,1-7H3;1H
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

What can I find under CRFR?
This listing collects compounds associated with CRFR within our GPCR/G Protein area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for CRFR?
Consider the reported potency of each CRFR compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for CRFR compounds?
Each CRFR product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search CRFR compounds by activity or structure?
Yes. Filter the CRFR listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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