Cyclophilin

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  1. Cyclosporine
    CAS: 79217-60-0 Formula: C62H111N11O12 Molecular Weight: 1202.61
    ● In Stock — US warehouse, ships to EU* Item #: C129997
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    Technical Identifiers
    IUPAC Name
    30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,show more
    SMILES
    CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)Cshow more
    InChIKey
    PMATZTZNYRCHOR-KMSBSJHKSA-N
    InChI
    1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(show more
    Synonyms
    30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpr...
  2. Cyclosporin A, Cyclophilin A modulator
    CAS: 59865-13-3 EC Number: 611-907-1 PubChem CID: 5284373 Formula: C62H111N11O12 Molecular Weight: 1202.61
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C106893
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    IUPAC Name
    (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-meshow more
    SMILES
    CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)Cshow more
    InChIKey
    PMATZTZNYRCHOR-CGLBZJNRSA-N
    InChI
    1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(show more
    Synonyms
    Cicloral (antibiotic) | cyclosporine | CYCLOSPORINE [HSDB] | Cyclosporine [USAN:USP] | CYCLOSPORINE [VANDF] | Prestwi...
  3. TMN 355
    CAS: 1186372-20-2 PubChem CID: 44249042 Formula: C21H14ClFN2O2 Molecular Weight: 380.8
    ● In Stock — US warehouse, ships to EU* Item #: T287318
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    IUPAC Name
    2-chloro-N-(9H-fluoren-9-ylcarbamoyl)-6-fluorobenzamide
    SMILES
    C1=CC=C2C(=C1)C(C3=CC=CC=C32)NC(=O)NC(=O)C4=C(C=CC=C4Cl)F
    InChIKey
    SFNLLCUAISZNRV-UHFFFAOYSA-N
    InChI
    1S/C21H14ClFN2O2/c22-16-10-5-11-17(23)18(16)20(26)25-21(27)24-19-14-8-3-1-6-12(14)13-7-2-4-9-15(13)19/h1-11,19H,(H2,24,25,26,27)
    Synonyms
    2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
  4. TMN 355
    CAS: 1186372-20-2 PubChem CID: 44249042 Formula: C21H14ClFN2O2 Molecular Weight: 380.8
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T420822
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    Technical Identifiers
    IUPAC Name
    2-chloro-N-(9H-fluoren-9-ylcarbamoyl)-6-fluorobenzamide
    SMILES
    C1=CC=C2C(=C1)C(C3=CC=CC=C32)NC(=O)NC(=O)C4=C(C=CC=C4Cl)F
    InChIKey
    SFNLLCUAISZNRV-UHFFFAOYSA-N
    InChI
    1S/C21H14ClFN2O2/c22-16-10-5-11-17(23)18(16)20(26)25-21(27)24-19-14-8-3-1-6-12(14)13-7-2-4-9-15(13)19/h1-11,19H,(H2,24,25,26,27)
    Synonyms
    2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
  5. NIM811
    CAS: 143205-42-9 PubChem CID: 6473876 Formula: C62H111N11O12 Molecular Weight: 1202.61
    ◐ .Made to order · 8–12 wks Item #: N646687
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    Technical Identifiers
    IUPAC Name
    (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-24-[(2S)-butan-2-yl]-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,show more
    SMILES
    CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)Cshow more
    InChIKey
    RPJPZDVUUKWPGT-FOIHOXPVSA-N
    InChI
    1S/C62H111N11O12/c1-25-28-29-40(15)52(75)51-56(79)65-43(27-3)58(81)67(18)33-47(74)71(22)50(39(14)26-2)55(78)66-48(37(10)11)61(84)68(19)44(30-34(4)5)54show more
    Synonyms
    (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-24-[(2S)-butan-2-yl]-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,...
  6. Alisporivir, Cyclophilin A inhibitor
    CAS: 254435-95-5 EC Number: 807-328-0 PubChem CID: 11513676 Formula: C63H113N11O12 Molecular Weight: 1216.64
    ◐ .Made to order · 8–12 wks Item #: A647986
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    Technical Identifiers
    IUPAC Name
    (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-25,30-diethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,27,28-nonamethyl-6,9,18-tris(2-show more
    SMILES
    CCC1C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)show more
    InChIKey
    OLROWHGDTNFZBH-XEMWPYQTSA-N
    InChI
    1S/C63H113N11O12/c1-26-29-30-40(16)52(75)51-56(79)66-44(27-2)59(82)68(20)43(19)58(81)74(28-3)49(38(12)13)55(78)67-48(37(10)11)62(85)69(21)45(31-34(4)5show more
    Synonyms
    DEB025 | DEB-025 | DTXSID30921552 | (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-25,30-diethyl-33-((1R,2R,E)-1-hydroxy-...
  7. CypD-IN-29
    CAS: 1115335-95-9 PubChem CID: 49658644
    ◐ .Made to order · 8–12 wks Item #: C1434405
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    Technical Identifiers
    IUPAC Name
    3-[2-[2-(2-cyanoanilino)-2-oxoethyl]sulfanylimidazol-1-yl]-N-[(4-fluorophenyl)methyl]benzamide
    SMILES
    C1=CC=C(C(=C1)C#N)NC(=O)CSC2=NC=CN2C3=CC=CC(=C3)C(=O)NCC4=CC=C(C=C4)F
    InChIKey
    WAPJUYVZASTWRM-UHFFFAOYSA-N
    InChI
    1S/C26H20FN5O2S/c27-21-10-8-18(9-11-21)16-30-25(34)19-5-3-6-22(14-19)32-13-12-29-26(32)35-17-24(33)31-23-7-2-1-4-20(23)15-28/h1-14H,16-17H2,(H,30,34)(show more
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Frequently Asked Questions

How is the Cyclophilin listing put together?
It draws on reported Cyclophilin annotations within Immunology/Inflammation and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a Cyclophilin modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the Cyclophilin entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for Cyclophilin compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For Cyclophilin work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the Cyclophilin compound I need is not listed?
Search by CAS number or SMILES first, since analogs of Cyclophilin compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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