Dihydroorotate Dehydrogenase

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  1. Leflunomide, Dihydroorotate dehydrogenase inhibitor
    CAS: 75706-12-6 EC Number: 616-254-6 Formula: C12H9F3N2O2 Molecular Weight: 270.21
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: L129518
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    IUPAC Name
    5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
    SMILES
    CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
    InChIKey
    VHOGYURTWQBHIL-UHFFFAOYSA-N
    InChI
    1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
    Synonyms
    HWA486 | RS-34821 | L 5025 | leflunomide | SU 101 | UNII-G162GK9U4W | HMS2235C07 | HMS3371F21 | lefunamide | 5-Methyl...
  2. Tenovin-1
    CAS: 380315-80-0 PubChem CID: 1013376 Formula: C20H23N3O2S Molecular Weight: 369.48
    ● In Stock — US warehouse, ships to EU* Item #: T125146
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    IUPAC Name
    N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
    SMILES
    CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C
    InChIKey
    WOWJIWFCOPZFGV-UHFFFAOYSA-N
    InChI
    1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)
    Synonyms
    Q27166342 | SR-01000946350-1 | CCG-208685 | N-(4-acetamidophenylcarbamothioyl)-4-tert-butylbenzamide | HY-13423 | SW1...
  3. Tenovin-6
    CAS: 1011557-82-6 PubChem CID: 24772043 Formula: C25H34N4O2S Molecular Weight: 454.6
    ● In Stock — US warehouse, ships to EU* Item #: T338048
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    IUPAC Name
    4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
    SMILES
    CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C
    InChIKey
    BVJSXSQRIUSRCO-UHFFFAOYSA-N
    InChI
    1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,show more
    Synonyms
    1011557-82-6 | SR-01000946351 | EX-A350 | AS-16762 | 4-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)butanoicacid | SR-0100094...
  4. Brequinar (DUP785), Dihydroorotate dehydrogenase inhibitor
    CAS: 96187-53-0 Formula: C23H15F2NO2 Molecular Weight: 375.37
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: B405327
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    IUPAC Name
    6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
    SMILES
    CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O
    InChIKey
    PHEZJEYUWHETKO-UHFFFAOYSA-N
    InChI
    1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
    Synonyms
    BCP06006 | brequinarum | EX-A1515 | 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid | 4...
  5. Lapachol
    CAS: 84-79-7 EC Number: 201-563-7 Formula: C15H14O3 Molecular Weight: 242.27
    ● In Stock — US warehouse, ships to EU* Item #: L137385
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    IUPAC Name
    4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione
    SMILES
    CC(=CCC1=C(C2=CC=CC=C2C(=O)C1=O)O)C
    InChIKey
    CWPGNVFCJOPXFB-UHFFFAOYSA-N
    InChI
    1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,16H,8H2,1-2H3
    Synonyms
    NINDS_000594 | SPBio_001341 | Surinam greenheart wood | Taiguic acid | NCGC00094931-01 | HMS3869D03 | Spectrum3_00076...
  6. AG-636
    CAS: 1623416-31-8 Formula: C21H17N3O2 Molecular Weight: 343.38
    ● In Stock — US warehouse, ships to EU* Item #: A414482
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    IUPAC Name
    3-methyl-6-[4-(2-methylphenyl)phenyl]benzotriazole-4-carboxylic acid
    SMILES
    CC1=CC=CC=C1C2=CC=C(C=C2)C3=CC(=C4C(=C3)N=NN4C)C(=O)O
    InChIKey
    GSBZRCGZLMBSNY-UHFFFAOYSA-N
    InChI
    1S/C21H17N3O2/c1-13-5-3-4-6-17(13)15-9-7-14(8-10-15)16-11-18(21(25)26)20-19(12-16)22-23-24(20)2/h3-12H,1-2H3,(H,25,26)
    Synonyms
    1H-​Benzotriazole-​7-​carboxylic acid,1-​methyl-​5-​(2'-​methyl[1,​1'-​biphenyl]​-​4-​yl)​-
  7. AG-636
    CAS: 1623416-31-8 Formula: C21H17N3O2 Molecular Weight: 343.38
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: A421973
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    Technical Identifiers
    IUPAC Name
    3-methyl-6-[4-(2-methylphenyl)phenyl]benzotriazole-4-carboxylic acid
    SMILES
    CC1=CC=CC=C1C2=CC=C(C=C2)C3=CC(=C4C(=C3)N=NN4C)C(=O)O
    InChIKey
    GSBZRCGZLMBSNY-UHFFFAOYSA-N
    InChI
    1S/C21H17N3O2/c1-13-5-3-4-6-17(13)15-9-7-14(8-10-15)16-11-18(21(25)26)20-19(12-16)22-23-24(20)2/h3-12H,1-2H3,(H,25,26)
    Synonyms
    1H-​Benzotriazole-​7-​carboxylic acid,1-​methyl-​5-​(2'-​methyl[1,​1'-​biphenyl]​-​4-​yl)​-
  8. ASLAN003, Dihydroorotate dehydrogenase inhibitor
    CAS: 1035688-66-4 Formula: C19H14F2N2O3 Molecular Weight: 356.32
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: A414476
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    IUPAC Name
    2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid
    SMILES
    COC1=CC=CC(=C1)C2=CC(=C(C(=C2)F)NC3=C(C=CC=N3)C(=O)O)F
    InChIKey
    OMPATGZMNFWVOH-UHFFFAOYSA-N
    InChI
    1S/C19H14F2N2O3/c1-26-13-5-2-4-11(8-13)12-9-15(20)17(16(21)10-12)23-18-14(19(24)25)6-3-7-22-18/h2-10H,1H3,(H,22,23)(H,24,25)
    Synonyms
    2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid | ASALN003 | UNII-I58WE41H6X | MFCD32215342 | G...
  9. ASLAN003, Dihydroorotate dehydrogenase inhibitor
    CAS: 1035688-66-4 Formula: C19H14F2N2O3 Molecular Weight: 356.32
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: A420429
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    Technical Identifiers
    IUPAC Name
    2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid
    SMILES
    COC1=CC=CC(=C1)C2=CC(=C(C(=C2)F)NC3=C(C=CC=N3)C(=O)O)F
    InChIKey
    OMPATGZMNFWVOH-UHFFFAOYSA-N
    InChI
    1S/C19H14F2N2O3/c1-26-13-5-2-4-11(8-13)12-9-15(20)17(16(21)10-12)23-18-14(19(24)25)6-3-7-22-18/h2-10H,1H3,(H,22,23)(H,24,25)
    Synonyms
    2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid | ASALN003 | UNII-I58WE41H6X | MFCD32215342 | G...
  10. BAY 2402234, Inhibitor of dihydroorotate dehydrogenase (quinone)
    CAS: 2225819-06-5 Formula: C21H18ClF5N4O4 Molecular Weight: 520.84
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: B414218
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    IUPAC Name
    N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-1,2,4-triazol-1-yl]-5-fluoro-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzamide
    SMILES
    CCN1C(=NN(C1=O)C2=C(C=C(C(=C2)OC(C)C(F)(F)F)C(=O)NC3=C(C=CC=C3Cl)F)F)CO
    InChIKey
    KNVJMHHAXCPZHF-JTQLQIEISA-N
    InChI
    1S/C21H18ClF5N4O4/c1-3-30-17(9-32)29-31(20(30)34)15-8-16(35-10(2)21(25,26)27)11(7-14(15)24)19(33)28-18-12(22)5-4-6-13(18)23/h4-8,10,32H,3,9H2,1-2H3,(Hshow more
    Synonyms
    AKOS040741291 | s8847 | N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1...
  11. BAY 2402234, Inhibitor of dihydroorotate dehydrogenase (quinone)
    CAS: 2225819-06-5 Formula: C21H18ClF5N4O4 Molecular Weight: 520.84
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: B422666
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    Technical Identifiers
    IUPAC Name
    N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-1,2,4-triazol-1-yl]-5-fluoro-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzamide
    SMILES
    CCN1C(=NN(C1=O)C2=C(C=C(C(=C2)OC(C)C(F)(F)F)C(=O)NC3=C(C=CC=C3Cl)F)F)CO
    InChIKey
    KNVJMHHAXCPZHF-JTQLQIEISA-N
    InChI
    1S/C21H18ClF5N4O4/c1-3-30-17(9-32)29-31(20(30)34)15-8-16(35-10(2)21(25,26)27)11(7-14(15)24)19(33)28-18-12(22)5-4-6-13(18)23/h4-8,10,32H,3,9H2,1-2H3,(Hshow more
    Synonyms
    AKOS040741291 | s8847 | N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1...
  12. Brequinar, Dihydroorotate dehydrogenase inhibitor
    CAS: 96187-53-0 EC Number: 887-847-7 Formula: C23H15F2NO2 Molecular Weight: 375.37
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: B427162
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    Technical Identifiers
    IUPAC Name
    6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
    SMILES
    CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O
    InChIKey
    PHEZJEYUWHETKO-UHFFFAOYSA-N
    InChI
    1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
    Synonyms
    BCP06006 | brequinarum | EX-A1515 | 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid | 4...
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Frequently Asked Questions

Which compounds are listed for Dihydroorotate Dehydrogenase?
Compounds associated with Dihydroorotate Dehydrogenase are grouped here under the Metabolic Enzyme/Protease classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Dihydroorotate Dehydrogenase sit within Metabolic Enzyme/Protease?
Dihydroorotate Dehydrogenase is one target listing within the Metabolic Enzyme/Protease classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Dihydroorotate Dehydrogenase?
For compounds listed under Dihydroorotate Dehydrogenase, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Dihydroorotate Dehydrogenase?
Browse the parent Metabolic Enzyme/Protease listing to reach targets neighbouring Dihydroorotate Dehydrogenase, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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