Dihydroorotate Dehydrogenase

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  1. DHODH-IN-11
    CAS: 1263303-95-2 Formula: C15H11N3O2 Molecular Weight: 265.27
    ● In Stock — US warehouse, ships to EU* Item #: D412523
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    IUPAC Name
    (2E)-2-cyano-2-hydroxyimino-N-(4-phenylphenyl)acetamide
    SMILES
    C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C(=NO)C#N
    InChIKey
    YFGFEIDPJVPFOM-NBVRZTHBSA-N
    InChI
    1S/C15H11N3O2/c16-10-14(18-20)15(19)17-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,20H,(H,17,19)/b18-14+
    Synonyms
    EX-A4388 | AKOS040732964 | (E)-2-([1,1'-Biphenyl]-4-ylamino)-N-hydroxy-2-oxoacetimidoylcyanide | (E)-2-([1,1'-Bipheny...
  2. Lapachol
    CAS: 84-79-7 EC Number: 201-563-7 Formula: C15H14O3 Molecular Weight: 242.27
    10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: L426218
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    IUPAC Name
    4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione
    SMILES
    CC(=CCC1=C(C2=CC=CC=C2C(=O)C1=O)O)C
    InChIKey
    CWPGNVFCJOPXFB-UHFFFAOYSA-N
    InChI
    1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,16H,8H2,1-2H3
    Synonyms
    NINDS_000594 | SPBio_001341 | Surinam greenheart wood | Taiguic acid | NCGC00094931-01 | HMS3869D03 | Spectrum3_00076...
  3. ML390
    CAS: 2029049-79-2 PubChem CID: 71768304 Formula: C21H21F3N2O3 Molecular Weight: 406.4
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: M422468
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    IUPAC Name
    N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propyl]-4-(trifluoromethoxy)benzamide
    SMILES
    C1CC(C2=CC=CC=C2C1)NC(=O)CCNC(=O)C3=CC=C(C=C3)OC(F)(F)F
    InChIKey
    SGNRHEDBLPGDDC-GOSISDBHSA-N
    InChI
    1S/C21H21F3N2O3/c22-21(23,24)29-16-10-8-15(9-11-16)20(28)25-13-12-19(27)26-18-7-3-5-14-4-1-2-6-17(14)18/h1-2,4,6,8-11,18H,3,5,7,12-13H2,(H,25,28)(H,26show more
    Synonyms
    N-(2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)ethyl)-4-(trifluoromethoxy)benzamide
  4. ML390
    CAS: 2029049-79-2 PubChem CID: 71768304 Formula: C21H21F3N2O3 Molecular Weight: 406.4
    ● In Stock — US warehouse, ships to EU* Item #: M413994
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    IUPAC Name
    N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propyl]-4-(trifluoromethoxy)benzamide
    SMILES
    C1CC(C2=CC=CC=C2C1)NC(=O)CCNC(=O)C3=CC=C(C=C3)OC(F)(F)F
    InChIKey
    SGNRHEDBLPGDDC-GOSISDBHSA-N
    InChI
    1S/C21H21F3N2O3/c22-21(23,24)29-16-10-8-15(9-11-16)20(28)25-13-12-19(27)26-18-7-3-5-14-4-1-2-6-17(14)18/h1-2,4,6,8-11,18H,3,5,7,12-13H2,(H,25,28)(H,26show more
    Synonyms
    N-(2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)ethyl)-4-(trifluoromethoxy)benzamide | (R)-N-(3-oxo-3-((1,2,3,4-...
  5. Tenovin-6
    CAS: 1011557-82-6 PubChem CID: 24772043 Formula: C25H34N4O2S Molecular Weight: 454.6
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T420311
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    IUPAC Name
    4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
    SMILES
    CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C
    InChIKey
    BVJSXSQRIUSRCO-UHFFFAOYSA-N
    InChI
    1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,show more
    Synonyms
    1011557-82-6 | SR-01000946351 | EX-A350 | AS-16762 | 4-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)butanoicacid | SR-0100094...
  6. Teriflunomide, Inhibitor of dihydroorotate dehydrogenase (quinone)
    CAS: 108605-62-5 PubChem CID: 54684141 Formula: C12H9F3N2O2 Molecular Weight: 270.21
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: T129937
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    IUPAC Name
    (Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
    SMILES
    CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
    InChIKey
    UTNUDOFZCWSZMS-YFHOEESVSA-N
    InChI
    1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
    Synonyms
    J-010046 | MFCD00910058 | HY-110159 | NCGC00263218-07 | A771726 | A-771726 | A77-1726 | A801897 | SW219377-1 | 2-Bute...
  7. Vidofludimus, Dihydroorotate dehydrogenase inhibitor
    CAS: 717824-30-1 EC Number: 615-418-4 PubChem CID: 9820008 Formula: C20H18FNO4 Molecular Weight: 355.36
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: V425644
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    IUPAC Name
    2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid
    SMILES
    COC1=CC=CC(=C1)C2=CC(=C(C=C2)NC(=O)C3=C(CCC3)C(=O)O)F
    InChIKey
    XPRDUGXOWVXZLL-UHFFFAOYSA-N
    InChI
    1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25)
    Synonyms
    EX-A4148 | s7262 | (+/-) ethylnipecotate | 2,2'-Anhydro(1.beta.-D-arabinofuranosyl)uracil | NCGC00246751-01 | NCGC003...
  8. Vidofludimus, Dihydroorotate dehydrogenase inhibitor
    CAS: 717824-30-1 EC Number: 615-418-4 PubChem CID: 9820008 Formula: C20H18FNO4 Molecular Weight: 355.36
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: V413727
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    Technical Identifiers
    IUPAC Name
    2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid
    SMILES
    COC1=CC=CC(=C1)C2=CC(=C(C=C2)NC(=O)C3=C(CCC3)C(=O)O)F
    InChIKey
    XPRDUGXOWVXZLL-UHFFFAOYSA-N
    InChI
    1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25)
    Synonyms
    EX-A4148 | s7262 | (+/-) ethylnipecotate | 2,2'-Anhydro(1.beta.-D-arabinofuranosyl)uracil | NCGC00246751-01 | NCGC003...
  9. hDHODH-IN-1
    CAS: 1173715-42-8 Formula: C17H14N2O2 Molecular Weight: 278.31
    ● In Stock — US warehouse, ships to EU* Item #: H412522
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    IUPAC Name
    (Z)-2-cyano-3-hydroxy-N-(4-phenylphenyl)but-2-enamide
    SMILES
    CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C2=CC=CC=C2)O
    InChIKey
    MUVPBAIVOHJDOC-VBKFSLOCSA-N
    InChI
    1S/C17H14N2O2/c1-12(20)16(11-18)17(21)19-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,20H,1H3,(H,19,21)/b16-12-
  10. BRD9185, Inhibitor of dihydroorotate dehydrogenase (quinone)
    CAS: 2057420-29-6 PubChem CID: 121596187
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: B608212
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    IUPAC Name
    (2S,3S,4S)-3-[4-[3,4-bis(trifluoromethyl)phenyl]phenyl]-2-cyano-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide
    SMILES
    CCCNC(=O)N1C(C(C1C#N)C2=CC=C(C=C2)C3=CC(=C(C=C3)C(F)(F)F)C(F)(F)F)CO
    InChIKey
    FYPZBZFXJUJJRA-AQNXPRMDSA-N
    InChI
    1S/C23H21F6N3O2/c1-2-9-31-21(34)32-18(11-30)20(19(32)12-33)14-5-3-13(4-6-14)15-7-8-16(22(24,25)26)17(10-15)23(27,28)29/h3-8,10,18-20,33H,2,9,12H2,1H3,show more
    Synonyms
    compound 27
  11. DSM502, Plasmodium falciparum dihydroorotate dehydrogenase
    CAS: 2426616-55-7 Formula: C16H16F3N3O Molecular Weight: 323.31
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: D609991
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    Synonyms
    N-cyclopropyl-3-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1H-pyrrole-2-carboxamide
  12. PTC299, Dihydroorotate dehydrogenase inhibitor
    CAS: 1256565-36-2 PubChem CID: 49787172 Formula: C25H20Cl2N2O3 Molecular Weight: 467.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: E610114
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    IUPAC Name
    (4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
    SMILES
    COC1=CC=C(C=C1)C2C3=C(CCN2C(=O)OC4=CC=C(C=C4)Cl)C5=C(N3)C=CC(=C5)Cl
    InChIKey
    SRSHBZRURUNOSM-DEOSSOPVSA-N
    InChI
    1S/C25H20Cl2N2O3/c1-31-18-7-2-15(3-8-18)24-23-20(21-14-17(27)6-11-22(21)28-23)12-13-29(24)25(30)32-19-9-4-16(26)5-10-19/h2-11,14,24,28H,12-13H2,1H3/t2show more
    Synonyms
    Emvododstat | (4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate ...
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Frequently Asked Questions

Which compounds are listed for Dihydroorotate Dehydrogenase?
Compounds associated with Dihydroorotate Dehydrogenase are grouped here under the Metabolic Enzyme/Protease classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Dihydroorotate Dehydrogenase sit within Metabolic Enzyme/Protease?
Dihydroorotate Dehydrogenase is one target listing within the Metabolic Enzyme/Protease classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Dihydroorotate Dehydrogenase?
For compounds listed under Dihydroorotate Dehydrogenase, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Dihydroorotate Dehydrogenase?
Browse the parent Metabolic Enzyme/Protease listing to reach targets neighbouring Dihydroorotate Dehydrogenase, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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