DYRK

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  1. AZ Dyrk1B 33
    CAS: 1679330-37-0 Formula: C19H16N4 Molecular Weight: 300.36
    ● In Stock — US warehouse, ships to EU* Item #: A287637
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    Technical Identifiers
    IUPAC Name
    1-benzyl-3-(2-methylpyrimidin-4-yl)pyrrolo[2,3-c]pyridine
    SMILES
    CC1=NC=CC(=N1)C2=CN(C3=C2C=CN=C3)CC4=CC=CC=C4
    InChIKey
    CZCUSHJQJWKYTD-UHFFFAOYSA-N
    InChI
    1S/C19H16N4/c1-14-21-10-8-18(22-14)17-13-23(12-15-5-3-2-4-6-15)19-11-20-9-7-16(17)19/h2-11,13H,12H2,1H3
    Synonyms
    3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
  2. GSK 626616
    CAS: 1025821-33-3 EC Number: 852-159-8 Formula: C18H10Cl2N4OS Molecular Weight: 401.27
    ● In Stock — US warehouse, ships to EU* Item #: G302093
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    IUPAC Name
    (5Z)-2-(2,6-dichlorophenyl)imino-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidin-4-one
    SMILES
    C1=CC(=C(C(=C1)Cl)N=C2NC(=O)C(=CC3=CC4=NC=CN=C4C=C3)S2)Cl
    InChIKey
    RJPNRXFBYZVRIB-DHDCSXOGSA-N
    InChI
    1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-
    Synonyms
    (5Z)-2-(2,6-dichloroanilino)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazol-4-one | Z3476101065 | 1025821-33-3 | GSK62661...
  3. Harmine, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1B
    CAS: 442-51-3 EC Number: 207-131-4 Formula: C13H12N2O Molecular Weight: 212.25
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: H423993
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    IUPAC Name
    7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
    SMILES
    CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
    InChIKey
    BXNJHAXVSOCGBA-UHFFFAOYSA-N
    InChI
    1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
    Synonyms
    7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole | HARMINE | HMS3885E10 | Spectrum5_001914 | 9H-Pyrido(3,4-b)indole, 7-metho...
  4. Harmine Hydrochloride
    CAS: 343-27-1 EC Number: 206-443-8 Formula: C13H12N2O·HCl Molecular Weight: 248.71
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: H423503
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    IUPAC Name
    7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
    SMILES
    CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC.Cl
    InChIKey
    VNPLYCKZIUTKJM-UHFFFAOYSA-N
    InChI
    1S/C13H12N2O.ClH/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;/h3-7,15H,1-2H3;1H
    Synonyms
    AC-34980 | Banisterine Hydrochloride | A-8200 | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride | DTXCID10683...
  5. ID 8
    CAS: 147591-46-6 EC Number: 663-653-6 Formula: C16H14N2O4 Molecular Weight: 298.29
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: I421723
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    Technical Identifiers
    IUPAC Name
    1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
    SMILES
    CC1=C(C2=C(N1C3=CC=C(C=C3)OC)C=C(C=C2)O)[N+](=O)[O-]
    InChIKey
    VVZNWYXIOADGSW-UHFFFAOYSA-N
    InChI
    1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
    Synonyms
    ID-8|147591-46-6|1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol|ID 8|1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-...
  6. ML-167
    CAS: 1285702-20-6 EC Number: 808-432-9 Formula: C19H17N3O3 Molecular Weight: 335.36
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: M421145
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    Technical Identifiers
    IUPAC Name
    [5-[4-[(5-methylfuran-2-yl)methylamino]quinazolin-6-yl]furan-2-yl]methanol
    SMILES
    CC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO
    InChIKey
    ROCFOIBAEVAOLQ-UHFFFAOYSA-N
    InChI
    1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
    Synonyms
    NCGC00188654-04 | [5-(4-{[(5-METHYLFURAN-2-YL)METHYL]AMINO}QUINAZOLIN-6-YL)FURAN-2-YL]METHANOL | BDBM50342913 | AC-35...
  7. ProINDY
    CAS: 719277-30-2 PubChem CID: 44633738 Formula: C14H15NO3S Molecular Weight: 277.34
    ● In Stock — US warehouse, ships to EU* Item #: P287544
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    IUPAC Name
    [(2Z)-3-ethyl-2-(2-oxopropylidene)-1,3-benzothiazol-5-yl] acetate
    SMILES
    CCN1C2=C(C=CC(=C2)OC(=O)C)SC1=CC(=O)C
    InChIKey
    RLEOCVDWLAYGRX-AUWJEWJLSA-N
    InChI
    1S/C14H15NO3S/c1-4-15-12-8-11(18-10(3)17)5-6-13(12)19-14(15)7-9(2)16/h5-8H,4H2,1-3H3/b14-7-
    Synonyms
    (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone
  8. Protein kinase inhibitor 1 hydrochloride
    CAS: 2321337-71-5 Formula: C18H18ClN5O3S Molecular Weight: 419.89
    ● In Stock — US warehouse, ships to EU* Item #: P412118
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    SMILES
    O=C(NC/1=O)SC1=C\\C2=CNC(C(C3=CC=C(N4CCNCC4)N=C3)=C2)=O.[H]Cl
    Synonyms
    5-[[1,2-dihydro-2-oxo-6'-(1-piperazinyl)[3,3'-bipyridin]-5-yl]methylene]-2,4-thiazolidinedione hydrochloride
  9. 2-Amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
    CAS: 7355-55-7 EC Number: 876-045-2 Formula: C6H6N4O Molecular Weight: 150.14
    Solid ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: A590034
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    Technical Identifiers
    IUPAC Name
    2-amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
    SMILES
    C1=CNC2=C1C(=O)NC(=N2)N
    InChIKey
    OLAFFPNXVJANFR-UHFFFAOYSA-N
    InChI
    1S/C6H6N4O/c7-6-9-4-3(1-2-8-4)5(11)10-6/h1-2H,(H4,7,8,9,10,11)
    Synonyms
    MFCD09033259 | AC-22553 | QY8 | 2-azanyl-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one | 2-amino-3,7-dihydro-4H-pyrrolo[2,...
  10. (3R)-1-[3-[[3-amino-6-(2-fluoro-5-propan-2-yloxyphenyl)pyrazine-2-carbonyl]amino]pyridin-4-yl]piperidine-3-carboxylic acid, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of glycogen synthase kinase 3 beta
    CAS: 2041073-22-5 PubChem CID: 139600315 Formula: C25H27FN6O4 Molecular Weight: 494.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: R610621
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    Technical Identifiers
    IUPAC Name
    (3R)-1-[3-[[3-amino-6-(2-fluoro-5-propan-2-yloxyphenyl)pyrazine-2-carbonyl]amino]pyridin-4-yl]piperidine-3-carboxylic acid
    SMILES
    CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCCC(C4)C(=O)O)N
    InChIKey
    UZIATSFXNVOVFE-OAHLLOKOSA-N
    InChI
    1S/C25H27FN6O4/c1-14(2)36-16-5-6-18(26)17(10-16)19-12-29-23(27)22(30-19)24(33)31-20-11-28-8-7-21(20)32-9-3-4-15(13-32)25(34)35/h5-8,10-12,14-15H,3-4,9show more
    Synonyms
    4877
  11. leucettine L41, Inhibitor of CDC like kinase 1;Inhibitor of CDC like kinase 3;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 2;Inhibitor of dual specificity tyrosine phosp
    CAS: 1112978-84-3 PubChem CID: 135398522
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: L611491
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    Technical Identifiers
    IUPAC Name
    (4Z)-2-anilino-4-(1,3-benzodioxol-5-ylmethylidene)-1H-imidazol-5-one
    SMILES
    C1OC2=C(O1)C=C(C=C2)C=C3C(=O)NC(=N3)NC4=CC=CC=C4
    InChIKey
    PGPHHJBZEGSUNE-JYRVWZFOSA-N
    InChI
    1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8-
  12. EHT 5372
    CAS: 1425945-63-6 PubChem CID: 71529610 Formula: C17H11Cl2N5OS Molecular Weight: 404.27
    ◐ .Made to order · 8–12 wks Item #: E647460
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    Technical Identifiers
    IUPAC Name
    methyl 9-(2,4-dichloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate
    SMILES
    COC(=N)C1=NC2=C(S1)C3=C(C=C2)N=CN=C3NC4=C(C=C(C=C4)Cl)Cl
    InChIKey
    QSGKPYRFWJINEH-UHFFFAOYSA-N
    InChI
    1S/C17H11Cl2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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Frequently Asked Questions

How is the DYRK listing put together?
It draws on reported DYRK annotations within Protein Tyrosine Kinase/RTK and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a DYRK modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the DYRK entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for DYRK compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For DYRK work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the DYRK compound I need is not listed?
Search by CAS number or SMILES first, since analogs of DYRK compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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