JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

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  1. JAK2 Inhibitor V, Z3
    CAS: 195371-52-9 Formula: C23H24N2O Molecular Weight: 344.5
    ● In Stock — US warehouse, ships to EU* Item #: J339604
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    IUPAC Name
    2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one
    SMILES
    CC(CCC1=CC=CC=N1)(CCC2=CC=CC=N2)C(=O)C3=CC=CC=C3
    InChIKey
    SETYDCSRABYHSW-UHFFFAOYSA-N
    InChI
    1S/C23H24N2O/c1-23(15-13-20-11-5-7-17-24-20,16-14-21-12-6-8-18-25-21)22(26)19-9-3-2-4-10-19/h2-12,17-18H,13-16H2,1H3
    Synonyms
    S6524 | SMR001527222 | A14132 | BCP06498 | DTXSID40285798 | JAK2 Inhibitor V | HMS3092H09 | 2-methyl-1-phenyl-4-(pyri...
  2. JANEX-1, Tyrosine-protein kinase JAK3 inhibitor
    CAS: 202475-60-3 Formula: C16H15N3O3 Molecular Weight: 297.31
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: J422462
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    IUPAC Name
    4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
    SMILES
    COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
    InChIKey
    HOZUXBLMYUPGPZ-UHFFFAOYSA-N
    InChI
    1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
    Synonyms
    MFCD01862614 | 4-(4'-Hydroxylphenyl)-amino-6,7-dimethoxyquinazoline hydrochloride dihydrate | BDBM50227519 | AC-35236...
  3. JCN037
    CAS: 2305154-31-6 Formula: C16H11BrFN3O2 Molecular Weight: 376.18
    ● In Stock — US warehouse, ships to EU* Item #: J412606
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    IUPAC Name
    N-(3-bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
    SMILES
    C1COC2=C(O1)C=C3C(=C2)N=CN=C3NC4=C(C(=CC=C4)Br)F
    InChIKey
    MTLUFWWVOINWEL-UHFFFAOYSA-N
    InChI
    1S/C16H11BrFN3O2/c17-10-2-1-3-11(15(10)18)21-16-9-6-13-14(23-5-4-22-13)7-12(9)19-8-20-16/h1-3,6-8H,4-5H2,(H,19,20,21)
    Synonyms
    JGK037 | N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
  4. JND3229
    CAS: 2260886-64-2 Formula: C33H41ClN8O2 Molecular Weight: 617.18
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: J413666
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    IUPAC Name
    N-[4-[3-(2-chlorophenyl)-7-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]cyclohexyl]propanamide
    SMILES
    CCC(=O)NC1CCC(CC1)N2C3=NC(=NC=C3CN(C2=O)C4=CC=CC=C4Cl)NC5=CC(=C(C=C5)N6CCN(CC6)C)C
    InChIKey
    WVLWGBZNXIVAKC-UHFFFAOYSA-N
    InChI
    1S/C33H41ClN8O2/c1-4-30(43)36-24-9-12-26(13-10-24)42-31-23(21-41(33(42)44)29-8-6-5-7-27(29)34)20-35-32(38-31)37-25-11-14-28(22(2)19-25)40-17-15-39(3)1show more
    Synonyms
    N-(trans-4-(3-(2-Chlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]p...
  5. LFM-A13, Inhibitor of Bruton tyrosine kinase
    CAS: 244240-24-2 EC Number: 636-629-8 Formula: C11H8Br2N2O2 Molecular Weight: 360
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L422826
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    IUPAC Name
    (Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide
    SMILES
    CC(=C(C#N)C(=O)NC1=C(C=CC(=C1)Br)Br)O
    InChIKey
    UVSVTDVJQAJIFG-VURMDHGXSA-N
    InChI
    1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6-
    Synonyms
    CCG-100654 | NCGC00025100-02 | Lopac0_000650 | a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide | BDBM5055...
  6. Lazertinib, Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1903008-80-9 EC Number: 841-500-6 Formula: C30H34N8O3 Molecular Weight: 554.64
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: L414136
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    IUPAC Name
    N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide
    SMILES
    CN(C)CC1=CN(N=C1C2=CC=CC=C2)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC
    InChIKey
    RRMJMHOQSALEJJ-UHFFFAOYSA-N
    InChI
    1S/C30H34N8O3/c1-5-28(39)32-23-17-24(26(40-4)18-25(23)37-13-15-41-16-14-37)33-30-31-12-11-27(34-30)38-20-22(19-36(2)3)29(35-38)21-9-7-6-8-10-21/h5-12,show more
    Synonyms
    CCG-270023 | Leclaza | RRMJMHOQSALEJJ-UHFFFAOYSA-N | (E)-(3R,5S)-7-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,...
  7. Lapatinib ditosylate monohydrate, Epidermal growth factor receptor erbB1 inhibitor
    CAS: 388082-78-8 EC Number: 642-915-3 PubChem CID: 11557040 Formula: C43H44ClFN4O11S3 Molecular Weight: 943.49
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L423794
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    IUPAC Name
    N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid;hydshow more
    SMILES
    CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.O
    InChIKey
    XNRVGTHNYCNCFF-UHFFFAOYSA-N
    InChI
    1S/C29H26ClFN4O4S.2C7H8O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(3show more
    Synonyms
    388082-78-8|Lapatinib ditosylate hydrate|Tykerb|Lapatinib Ditosylate|LAPATINIB DITOSYLATE MONOHYDRATE|Tyverb|Tycerb|l...
  8. Lazertinib, Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1903008-80-9 EC Number: 841-500-6 Formula: C30H34N8O3 Molecular Weight: 554.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 2mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L422330
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    IUPAC Name
    N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide
    SMILES
    CN(C)CC1=CN(N=C1C2=CC=CC=C2)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC
    InChIKey
    RRMJMHOQSALEJJ-UHFFFAOYSA-N
    InChI
    1S/C30H34N8O3/c1-5-28(39)32-23-17-24(26(40-4)18-25(23)37-13-15-41-16-14-37)33-30-31-12-11-27(34-30)38-20-22(19-36(2)3)29(35-38)21-9-7-6-8-10-21/h5-12,show more
    Synonyms
    CCG-270023 | Leclaza | RRMJMHOQSALEJJ-UHFFFAOYSA-N | (E)-(3R,5S)-7-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,...
  9. Lentinan
    CAS: 37339-90-5 PubChem CID: 37723 Formula:
    Liquid 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L423679
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    Technical Identifiers
    IUPAC Name
    (2R,3R,4S,5S,6R)-2-[[(2R,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6show more
    SMILES
    C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)O
    InChIKey
    MAXBMUKIXLNXGX-DMWITZOWSA-N
    InChI
    1S/C42H72O36/c43-1-8-15(48)22(55)25(58)37(69-8)66-6-13-20(53)32(28(61)36(65)68-13)75-40-29(62)33(18(51)11(4-46)72-40)77-41-30(63)34(19(52)12(5-47)73-4show more
    Synonyms
    LENTINAN|37339-90-5|Bromoduline|Biomoduline|LC-33|UNII-6751655D1D|DRG-0171|Lentinan(Biomoduline)|SCHEMBL1517264|DTXSI...
  10. Lentinan
    CAS: 37339-90-5 PubChem CID: 37723 Formula:
    ● In Stock — US warehouse, ships to EU* Item #: L413225
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    IUPAC Name
    (2R,3R,4S,5S,6R)-2-[[(2R,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6show more
    SMILES
    C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)O
    InChIKey
    MAXBMUKIXLNXGX-DMWITZOWSA-N
    InChI
    1S/C42H72O36/c43-1-8-15(48)22(55)25(58)37(69-8)66-6-13-20(53)32(28(61)36(65)68-13)75-40-29(62)33(18(51)11(4-46)72-40)77-41-30(63)34(19(52)12(5-47)73-4show more
    Synonyms
    (2R,3R,4S,5S,6R)-2-[[(2R,3R,4S,5R,6R)-4-[[(2S,3R,4S,5R,6R)-4-[[(2S,3R,4S,5R,6R)-4-[[(2S,3R,4S,5R,6R)-3,5-dihydroxy-4-...
  11. Lifirafenib (BGB-283), Serine/threonine-protein kinase B-raf inhibitor
    CAS: 1446090-79-4 Formula: C25H17F3N4O3 Molecular Weight: 478.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: L413873
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    IUPAC Name
    5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-show more
    SMILES
    C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)OC5C4C5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F
    InChIKey
    NGFFVZQXSRKHBM-FKBYEOEOSA-N
    InChI
    1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20show more
    Synonyms
    BGB283 | BGB-283 | CAS-338-98-7 | D11410 | BGB-283;Beigene-283 | MS-28874 | 5-{{(1r,1as,6br)-1-[5-(trifluoromethyl)-1...
  12. 15(R)-Lipoxin A4, Agonist of FPR2/ALX
    CAS: 171030-11-8 Formula: C20H32O5 Molecular Weight: 352.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95% ~100ug/ml in ethanol
    ◐ .Made to order · 8–12 wks Item #: L342353
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    Technical Identifiers
    IUPAC Name
    (5S,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
    SMILES
    CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O
    InChIKey
    IXAQOQZEOGMIQS-JEWNPAEBSA-N
    InChI
    1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-show more
    Synonyms
    GTPL3933 | (5S,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid | AKOS040755721 | aspirin trigg...
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].

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