HCN Channel

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  1. Zatebradine hydrochloride
    CAS: 91940-87-3 PubChem CID: 3045335 Formula: C26H36N2O5•HCl Molecular Weight: 493.04
    ● In Stock — US warehouse, ships to EU* Item #: Z287734
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    IUPAC Name
    3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride
    SMILES
    CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CCC3=CC(=C(C=C3)OC)OC.Cl
    InChIKey
    ZRNKXJHEQKMWCH-UHFFFAOYSA-N
    InChI
    1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1show more
    Synonyms
    3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride ...
  2. ZD7288
    CAS: 133059-99-1 PubChem CID: 123983 Formula: C15H21N4 •Cl Molecular Weight: 292.81
    ● In Stock — US warehouse, ships to EU* Item #: Z274826
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    IUPAC Name
    N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine;hydrochloride
    SMILES
    CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
    InChIKey
    DUWKUHWHTPRMAP-UHFFFAOYSA-N
    InChI
    1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
    Synonyms
    BZ162628 | HB1152 | N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine monohydrochloride | ZD...
  3. 8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt
    CAS: 51239-26-0 Formula: C16H14ClN5NaO7PS Molecular Weight: 509.79
    ● In Stock — US warehouse, ships to EU* Item #: C336169
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    IUPAC Name
    sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-1show more
    SMILES
    C1C2C(C(C(O2)N3C4=C(C(=O)NC(=N4)N)N=C3SC5=CC=C(C=C5)Cl)O)OP(=O)(O1)[O-].[Na+]
    InChIKey
    REEQGIQRCDWDRA-ZBMQJGODSA-M
    InChI
    1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,show more
    Synonyms
    sodium 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate | 8-(4-chlorophenylthio)-3',5'-cyclic GMP.Na | 8-pC...
  4. Ivabradine HCl, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker
    CAS: 148849-67-6 PubChem CID: 3045381 Formula: C27H36N2O5 · HCl Molecular Weight: 505.05
    ● In Stock — US warehouse, ships to EU* Item #: I129899
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    IUPAC Name
    3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride
    SMILES
    CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl
    InChIKey
    HLUKNZUABFFNQS-ZMBIFBSDSA-N
    InChI
    1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17Hshow more
    Synonyms
    3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetr...
  5. DK-AH 269
    CAS: 186097-54-1 Formula: C28H39ClN2O5 Molecular Weight: 519.07
    ● In Stock — US warehouse, ships to EU* Item #: D350697
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    IUPAC Name
    3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride
    SMILES
    COC1=C(C=C(C=C1)CCN2CCCC(C2)CN3CCC4=CC(=C(C=C4CC3=O)OC)OC)OC.Cl
    InChIKey
    MTAKUIYCCYKGJJ-BOXHHOBZSA-N
    InChI
    1S/C28H38N2O5.ClH/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31;/h7-8,14-16,21H,5-6,9-1show more
    Synonyms
    HY-18940A | DTXSID10582024 | DK-AH 269 | 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethox...
  6. Rp-8-Br-cGMPS
    CAS: 150418-07-8 PubChem CID: 3035839 Formula: C10H11BrN5O6PS Molecular Weight: 440.17
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: R275791
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    IUPAC Name
    (2R,5R)-2-(2-amino-8-bromopurin-9-yl)-5-(dihydroxyphosphinothioyloxymethyl)-2,5-dihydrofuran-3,4-diol
    SMILES
    C1=C2C(=NC(=N1)N)N(C(=N2)Br)C3C(=C(C(O3)COP(=S)(O)O)O)O
    InChIKey
    NKBRWLDMUXONRI-SPGJFGJESA-N
    InChI
    1S/C10H11BrN5O6PS/c11-9-14-3-1-13-10(12)15-7(3)16(9)8-6(18)5(17)4(22-8)2-21-23(19,20)24/h1,4,8,17-18H,2H2,(H2,12,13,15)(H2,19,20,24)/t4-,8-/m1/s1
    Synonyms
    DTXSID20933942 | Rp-8-BrcGMPS | (R)-8-Bromoguanosine cyclic 3',5'-(hydrogen phosphorothioate) | O-{[5-(8-Bromo-2-imin...
  7. Ivabradine, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker
    CAS: 155974-00-8 PubChem CID: 132999 Formula: C27H36N2O5 Molecular Weight: 468.59
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: I611210
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    Technical Identifiers
    IUPAC Name
    3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one
    SMILES
    CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC
    InChIKey
    ACRHBAYQBXXRTO-OAQYLSRUSA-N
    InChI
    1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5show more
    Synonyms
    AB01566878_01 | AKOS015896494 | AT22349 | NCGC00181343-03 | S 16257 | 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,...
  8. Zatebradine, Channel blocker of HCN1;Channel blocker of HCN2;Channel blocker of HCN3;Channel blocker of HCN4
    CAS: 85175-67-3 Formula: C26H36N2O5 Molecular Weight: 456.57
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: Z614949
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    Technical Identifiers
    IUPAC Name
    3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one
    SMILES
    CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CCC3=CC(=C(C=C3)OC)OC
    InChIKey
    KEDQCFRVSHYKLR-UHFFFAOYSA-N
    InChI
    1S/C26H36N2O5/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29/h7-8,15-17H,6,9-14,18H2,1-5H3
    Synonyms
    3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one | 3-(3-{[2-...
  9. BPU-11
    CAS: 909664-41-1 PubChem CID: 24730758 Formula: C32H31N5O Molecular Weight: 501.63
    ◐ .Made to order · 8–12 wks Item #: B650026
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    IUPAC Name
    1-[1-[(3-cyanophenyl)methyl]piperidin-4-yl]-3-(2-phenylphenyl)-1-(pyridin-3-ylmethyl)urea
    SMILES
    C1CN(CCC1N(CC2=CN=CC=C2)C(=O)NC3=CC=CC=C3C4=CC=CC=C4)CC5=CC(=CC=C5)C#N
    InChIKey
    UIIRFZUAAAFHFB-UHFFFAOYSA-N
    InChI
    1S/C32H31N5O/c33-21-25-8-6-9-26(20-25)23-36-18-15-29(16-19-36)37(24-27-10-7-17-34-22-27)32(38)35-31-14-5-4-13-30(31)28-11-2-1-3-12-28/h1-14,17,20,22,2show more
  10. YM 758
    CAS: 312752-85-5 PubChem CID: 9894205
    ◐ .Made to order · 8–12 wks Item #: Y1048467
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    IUPAC Name
    N-[2-[(3R)-3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]ethyl]-4-fluorobenzamide
    SMILES
    COC1=C(C=C2CN(CCC2=C1)C(=O)C3CCCN(C3)CCNC(=O)C4=CC=C(C=C4)F)OC
    InChIKey
    MWLKUSHZNSYRKK-HXUWFJFHSA-N
    InChI
    1S/C26H32FN3O4/c1-33-23-14-19-9-12-30(17-21(19)15-24(23)34-2)26(32)20-4-3-11-29(16-20)13-10-28-25(31)18-5-7-22(27)8-6-18/h5-8,14-15,20H,3-4,9-13,16-17show more
  11. 2-{[4-ethyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-(10H-phenothiazin-10-yl)ethan-1-one
    CAS: 663212-40-6 PubChem CID: 1319471 Formula: C22H18N4O2S2 Molecular Weight: 434.53
    ◐ .Made to order · 8–12 wks Item #: E1060657
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    Technical Identifiers
    IUPAC Name
    2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-phenothiazin-10-ylethanone
    SMILES
    CCN1C(=NN=C1SCC(=O)N2C3=CC=CC=C3SC4=CC=CC=C42)C5=CC=CO5
    InChIKey
    ASZRHXKUEMHBKN-UHFFFAOYSA-N
    InChI
    1S/C22H18N4O2S2/c1-2-25-21(17-10-7-13-28-17)23-24-22(25)29-14-20(27)26-15-8-3-5-11-18(15)30-19-12-6-4-9-16(19)26/h3-13H,2,14H2,1H3
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Frequently Asked Questions

What can I find under HCN Channel?
This listing collects compounds associated with HCN Channel within our Membrane Transporter/Ion Channel area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for HCN Channel?
Consider the reported potency of each HCN Channel compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for HCN Channel compounds?
Each HCN Channel product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search HCN Channel compounds by activity or structure?
Yes. Filter the HCN Channel listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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