PI4K

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  1. MMV-390048
    CAS: 1314883-11-8 Formula: C18H14F3N3O2S Molecular Weight: 393.383
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: M173331
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    IUPAC Name
    5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine
    SMILES
    CS(=O)(=O)C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN=C(C=C3)C(F)(F)F
    InChIKey
    RTJQABCNNLMCJF-UHFFFAOYSA-N
    InChI
    1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
    Synonyms
    0Z5T00JJ10 | AKOS030628490 | SCHEMBL2225969 | 3-(2-(Trifluoromethyl)pyridin-5-yl)-5-(4-(methylsulfonyl)- phenyl)pyrid...
  2. PIK-93, Inhibitor of phosphatidylinositol 4-kinase beta
    CAS: 593960-11-3 Formula: C14H16ClN3O4S2 Molecular Weight: 389.88
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: P126888
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    IUPAC Name
    N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide
    SMILES
    CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO
    InChIKey
    JFVNFXCESCXMBC-UHFFFAOYSA-N
    InChI
    1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
    Synonyms
    DTXSID30425868 | N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide | NCGC00346536-...
  3. 4-(5-amino-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)-N-p-tolylpiperazine-1-carboxamide
    CAS: 1245319-54-3 Formula: C22H22N8OS Molecular Weight: 446.53
    ◐ .Made to order · 8–12 wks Item #: P126505
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    IUPAC Name
    4-(5-amino-2-pyridin-3-yl-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methylphenyl)piperazine-1-carboxamide
    SMILES
    CC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C4C(=NC(=N3)N)SC(=N4)C5=CN=CC=C5
    InChIKey
    UWTRKIJAGTTXNM-UHFFFAOYSA-N
    InChI
    1S/C22H22N8OS/c1-14-4-6-16(7-5-14)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)32-19(26-17)15-3-2-8-24-13-15/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,show more
    Synonyms
    VZB31954 | SCHEMBL655275 | 4-(5-Amino-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-7-yl)-N-(p-tolyl)piperazine-1-carboxam...
  4. BF 738735
    CAS: 1436383-95-7 Formula: C21H19FN4O3S Molecular Weight: 426.47
    ◐ .Made to order · 8–12 wks Item #: B286771
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    IUPAC Name
    2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol
    SMILES
    CC1=C(N2C=CN=C(C2=N1)NCC3=CC(=CC=C3)S(=O)(=O)C)C4=CC(=C(C=C4)O)F
    InChIKey
    IMHZCCZYPHJVMS-UHFFFAOYSA-N
    InChI
    1S/C21H19FN4O3S/c1-13-19(15-6-7-18(27)17(22)11-15)26-9-8-23-20(21(26)25-13)24-12-14-4-3-5-16(10-14)30(2,28)29/h3-11,27H,12H2,1-2H3,(H,23,24)
    Synonyms
    BF738735 | 2-Fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]phenol
  5. BQR695
    CAS: 1513879-21-4 Formula: C19H20N4O3 Molecular Weight: 352.39
    ● In Stock — US warehouse, ships to EU* Item #: B413524
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    IUPAC Name
    2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
    SMILES
    CNC(=O)CNC1=CN=C2C=CC(=CC2=N1)C3=CC(=C(C=C3)OC)OC
    InChIKey
    LYPCULYCGFOIDA-UHFFFAOYSA-N
    InChI
    1S/C19H20N4O3/c1-20-19(24)11-22-18-10-21-14-6-4-12(8-15(14)23-18)13-5-7-16(25-2)17(9-13)26-3/h4-10H,11H2,1-3H3,(H,20,24)(H,22,23)
    Synonyms
    NVP-BQR695 | 2-((7-(3,4-Dimethoxyphenyl)quinoxalin-2-yl)amino)-N-methylacetamide
  6. BQR695
    CAS: 1513879-21-4 Formula: C19H20N4O3 Molecular Weight: 352.39
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: B421795
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    Technical Identifiers
    IUPAC Name
    2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
    SMILES
    CNC(=O)CNC1=CN=C2C=CC(=CC2=N1)C3=CC(=C(C=C3)OC)OC
    InChIKey
    LYPCULYCGFOIDA-UHFFFAOYSA-N
    InChI
    1S/C19H20N4O3/c1-20-19(24)11-22-18-10-21-14-6-4-12(8-15(14)23-18)13-5-7-16(25-2)17(9-13)26-3/h4-10H,11H2,1-3H3,(H,20,24)(H,22,23)
    Synonyms
    NVP-BQR695;2-((7-(3,4-Dimethoxyphenyl)quinoxalin-2-yl)amino)-N-methylacetamide
  7. GSK-F1
    CAS: 1402345-92-9 Formula: C27H18F5N5O4S Molecular Weight: 603.52
    ● In Stock — US warehouse, ships to EU* Item #: G413022
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    IUPAC Name
    5-[2-amino-4-oxo-3-[2-(trifluoromethyl)phenyl]quinazolin-6-yl]-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide
    SMILES
    COC1=C(C=C(C=N1)C2=CC3=C(C=C2)N=C(N(C3=O)C4=CC=CC=C4C(F)(F)F)N)S(=O)(=O)NC5=C(C=C(C=C5)F)F
    InChIKey
    MSRFVAYVUUHQCN-UHFFFAOYSA-N
    InChI
    1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/show more
  8. KDU691
    CAS: 1513879-19-0 Formula: C22H18ClN5O2 Molecular Weight: 419.86
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: K421794
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    IUPAC Name
    N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
    SMILES
    CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C(=O)N(C)C4=CC=C(C=C4)Cl
    InChIKey
    TYMFFISSODJRDV-UHFFFAOYSA-N
    InChI
    1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29)
    Synonyms
    Imidazo[1,​2-​a]​pyrazine-​6-​carboxamide,N-​(4-​chlorophenyl)​-​N-​methyl-​3-​[4-​[(methylamino)​carbonyl]​phenyl]​-
  9. KDU691
    CAS: 1513879-19-0 Formula: C22H18ClN5O2 Molecular Weight: 419.86
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: K413526
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    Technical Identifiers
    IUPAC Name
    N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
    SMILES
    CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C(=O)N(C)C4=CC=C(C=C4)Cl
    InChIKey
    TYMFFISSODJRDV-UHFFFAOYSA-N
    InChI
    1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29)
    Synonyms
    Imidazo[1,​2-​a]​pyrazine-​6-​carboxamide,N-​(4-​chlorophenyl)​-​N-​methyl-​3-​[4-​[(methylamino)​carbonyl]​phenyl]​-...
  10. MI 14
    CAS: 1715934-43-2 Formula: C19H23ClN6O3S Molecular Weight: 450.94
    ◐ .Made to order · 8–12 wks Item #: M286762
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    IUPAC Name
    N-[2-[[6-chloro-3-[3-(dimethylsulfamoyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
    SMILES
    CC1=C(N2C(=N1)C(=CC(=N2)Cl)NCCNC(=O)C)C3=CC(=CC=C3)S(=O)(=O)N(C)C
    InChIKey
    PSTAJIONBVMKLA-UHFFFAOYSA-N
    InChI
    1S/C19H23ClN6O3S/c1-12-18(14-6-5-7-15(10-14)30(28,29)25(3)4)26-19(23-12)16(11-17(20)24-26)22-9-8-21-13(2)27/h5-7,10-11,22H,8-9H2,1-4H3,(H,21,27)
    Synonyms
    N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
  11. PI4KIIIbeta-IN-9
    CAS: 1429624-84-9 PubChem CID: 71533728 Formula: C23H25N3O5S2 Molecular Weight: 487.6
    ● In Stock — US warehouse, ships to EU* Item #: P412989
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    IUPAC Name
    N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]cyclopentanecarboxamide
    SMILES
    CC1=C(SC(=N1)NC(=O)C2CCCC2)C3=CC(=C(C=C3)OC)S(=O)(=O)NC4=CC=C(C=C4)O
    InChIKey
    KAXNDTMKFONXJM-UHFFFAOYSA-N
    InChI
    1S/C23H25N3O5S2/c1-14-21(32-23(24-14)25-22(28)15-5-3-4-6-15)16-7-12-19(31-2)20(13-16)33(29,30)26-17-8-10-18(27)11-9-17/h7-13,15,26-27H,3-6H2,1-2H3,(H,show more
  12. UCB9608
    CAS: 1616413-96-7 Formula: C20H26N8O2 Molecular Weight: 410.47
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: U412144
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    IUPAC Name
    (3S)-4-(6-amino-1-methylpyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamide
    SMILES
    CC1CN(CCN1C2=NC(=NC3=C2C=NN3C)N)C(=O)NC4=C(C=C(C=C4)OC)C
    InChIKey
    WRONAJQPZWDYAR-ZDUSSCGKSA-N
    InChI
    1S/C20H26N8O2/c1-12-9-14(30-4)5-6-16(12)23-20(29)27-7-8-28(13(2)11-27)18-15-10-22-26(3)17(15)24-19(21)25-18/h5-6,9-10,13H,7-8,11H2,1-4H3,(H,23,29)(H2,show more
    Synonyms
    1-​Piperazinecarboxamid​e,4-​(6-​amino-​1-​methyl-​1H-​pyrazolo[3,​4-​d]​pyrimidin-​4-​yl)​-​N-​(4-​methoxy-​2-​methy...
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Frequently Asked Questions

Which compounds are listed for PI4K?
Compounds associated with PI4K are grouped here under the PI3K/Akt/mTOR classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does PI4K sit within PI3K/Akt/mTOR?
PI4K is one target listing within the PI3K/Akt/mTOR classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from PI4K?
For compounds listed under PI4K, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for PI4K?
Browse the parent PI3K/Akt/mTOR listing to reach targets neighbouring PI4K, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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