Diisopropylcarbodiimide solution - 1 M in THF , CAS No.693-13-0

CAS: 693-13-0 Cat. No.: D433332 Molecular Weight: 126.20 Beilstein Registry Number: 878281 EC Number: 211-743-7
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GRADE & PURITY 1 M in THF
Synonyms
EINECS 211-743-7 | diisopropyl carbodiimide | N,N'-Diisopropyl carbodimide | dipropan-2-ylmethanediimine | N-((isopropylimino)methyl-ene)propan-2-amine | N-((isopropylimino)methylene)propan-2-amine | STR04127 | UNII-OQO20I6TWH | DIC, 99% | MFCD00065689 |
Storage
Room temperature
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Size
Status
Price
Qty
25ml
D433332-25ml
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100ml
D433332-100ml
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Why this grade

1 M in THF for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 75 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Application

DIC ( N,N ′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N -allylglycine to form N -allylpeptide. Valuable reagent offered as a solution in tetrahydrofuran for more convenient handling. Coupling reagent for peptide syntheses.

Specifications

Synonyms
EINECS 211-743-7 | diisopropyl carbodiimide | N, N'-Diisopropyl carbodimide | dipropan-2-ylmethanediimine | N-((isopropylimino)methyl-ene)propan-2-amine | N-((isopropylimino)methylene)propan-2-amine | STR04127 | UNII-OQO20I6TWH | DIC, 99% | MFCD00065689 |
Specifications & Purity
1 M in THF
Storage
Room temperature
Names and Identifiers
Canonical SmilesCC(C)N=C=NC(C)C
InChIKeyBDNKZNFMNDZQMI-UHFFFAOYSA-N
INCHI1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
Isomeric SMILES CC(C)N=C=NC(C)C
WGK Germany 3
RTECS FF2175000
UN Number 2929
Molecular Weight 126.20
Beilstein 878281
Reaxy-Rn 878281
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=878281&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Refractive Index1.433
Flash Point(°F)91°F
Flash Point(°C)31°C
Boil Point(°C)145-148°C
Molecular Weight126.200 g/mol
XLogP32.600
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass126.116 Da
Monoisotopic Mass126.116 Da
Topological Polar Surface Area24.700 Ų
Heavy Atom Count9
Formal Charge0
Complexity101.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
A Complete Guide to Choosing Resins for SPPS (Solid-Phase Peptide Synthesis): Fmoc/Boc Routes, C-Terminal Acid/Amide, and a Key-Parameter Navigator
β-Acyloxy Alkenyl Amides (AAAs): A New Approach to Amide Bond and Peptide Bond Construction Worth Attention
DAST-Mediated Amidation at Room Temperature: Method Features, Practical Value, and Scope of Applicability
From High Reactivity to Comprehensive Evaluation: Using CTSOAt as an Example to Understand the Design Logic of New Coupling Reagents
From Analytical Instrument to Synthetic Platform: A New Strategy for Reconstructing Automated Flow Solid-Phase Peptide Synthesis with Standard Analytical HPLC
New Progress in the Solid-Phase Synthesis of Sterically Hindered Peptides: Background, Core Breakthroughs, and Implications for Automation Compatibility of the RMMR Strategy
TCFH–NMI Amidation in Highly Aqueous Media: Research Value, Methodological Understanding, and Experimental Insights
A New Balance in Coupling Reagents: How DMT-TU Balances Reactivity, Racemization Control, and Thermal Hazard
The Positioning of TBTU in Practice: Racemization Risk, Extended Uses, and Selection Criteria
From “High Yield” to “Configuration Retention”: Activation-Stage Risks, Route Differences, and Selection Principles for Coupling Systems
The Methodological Value of HATU in Difficult Couplings: Reactivity Advantages, Stereochemical Retention, and Condition Management
The Methodological Value of Boc-Oxyma: Low-Racemization Coupling, Route Continuity, and Extended Applications
Low Racemization in Peptide Synthesis Is Not Just About Reagent Choice: Stereochemical Risk During the Activation Stage and Practical Strategies for Experimental Control
The Methodological Value of TCFH: Advantages in Challenging Amidation and the Switching Logic of Carboxylic Acid Activation Pathways
Ynamide Coupling Reagents: From Low-Epimerization Activation Pathways to More Practically Usable N→C Inverse Peptide Synthesis
Decision Logic for Peptide Synthesis Routes: Applicability and Criteria for Choosing among SPPS, LPPS, and Recombinant Expression
Decision Logic for Selecting Coupling Reagents in Amide Bond Formation: Activation Pathways, Side Reactions, Epimerization, Workup, and Safety
DMAP Is More Than Just an Organic Base: Experimental Judgment from Nucleophilic Acyl Transfer to Esterification and Macrolactonization
Experimental Assessment of HOPO in Carbodiimide-Mediated Amide Coupling: Low-Racemization Control, Application Scenarios, and Process Considerations
Experimental Selection Logic for Pentafluorophenyl-Based Systems: Practical Judgment from Active Esters and Pre-Activated Monomers to Downstream Transformations
Experimental Judgment in Oxyma Coupling Systems: Coupling Efficiency, Racemization Control, and the HCN Risk in DIC-Based Systems
Experimental Judgment for CMPI in Carboxylic Acid Activation: Applicable Tasks, Base Matching, and Workup Burden
Experimental Judgment for TFPN in Carboxylic Acid Activation: Suitable Scenarios, Intermediate Distribution, and Nucleophile Compatibility
Selective Acylation of Less Reactive Amines in Complex Substrates: Strategies for N/O and N/N Selectivity Control This article draws on the work of Li et al. on the TCFH/catalytic Oxyma system and transient imine protection, and summarizes design strateg
How to Troubleshoot Abnormal Impurities in Peptide Synthesis? Locating Process Issues Through Amino-Related Side Reactions
Peptide Intermediates Difficult to Dissolve and Separate? Route Design and Workup Strategies for Tag-Assisted Liquid-Phase Peptide Synthesis (TAG-LPPS)
Citations of This Product
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55. Zixu Xie, Chen Chen, Xinyu Chen, Fanqiang Bu, Guofeng Li, Pengfei Zhang, Xing Wang.  (2024)  In situ borneol-modified polyester with antibacterial adhesion and long-term fungal-repellent properties.  REACTIVE & FUNCTIONAL POLYMERS,      [PMID:] [10.1016/j.reactfunctpolym.2024.105993]
56. Jinfan Yang, Ning Shang, Zhengqing Li, Ji Xu, Xin Zhou, Hui Zhou, Wen Luo, Peng Xu, Yucheng Zhou, Xueru Sheng, Zheng Zhu, Mingzhen Zhang, Xiaojun Ma, Mingqian Tan, Hao Wu.  (2024)  Oral Lactoferrin-Responsive Formulation Anchoring around Inflammatory Bowel Region for IBD Therapy.  Advanced Healthcare Materials,      [PMID:39722174] [10.1002/adhm.202402731]
57. Chu Hongyu, Xu Yajun, Shan Yuezhan, Sun Mengmeng, Zhao Weidong, Fang Xuedong, Shen Na, Tang Zhaohui.  (2025)  Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-16).  [PMID:40059143] [10.1186/s12951-025-03262-9]
58. Zhongdong Tian, Yuan Gao, Peishu Tian, Silong Tian, Fengwei Shi, Jun Mei.  (2024)  Polymer Electrolytes with High Ionic Conductivities at Freezing Temperature for Aqueous Hybrid Batteries.  Chemistry-An Asian Journal,      [PMID:39487086] [10.1002/asia.202401110]
59. Shengjie Hu, Rumeng Zhao, Yuchen Tang, Tingjuan Gao.  (2025)  Rapid solid-phase microProbing of soil and groundwater lead and cadmium by tuning hydrophilic and hydrophobic microenvironments.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40120269] [10.1016/j.jhazmat.2025.137907]
60. Beibei Zhang, Hao Liu, Yifei Wang, Yong Zhang.  (2024)  ROS-Responsive and Self-Catalytic Nanocarriers for a Combination of Chemotherapy and Reinforced Ferroptosis against Breast Cancer.  ACS Biomaterials Science & Engineering,      [PMID:39262329] [10.1021/acsbiomaterials.4c01233]
61. Xitong Ren, Haochen Yao, Jiali Sun, Fuxin Xue, Linjie Cui, Yajun Xu, Kazuo Sakurai, Na Shen, Zhaohui Tang.  (2024)  ROS-responsive TLR7/8 nanoagonist and ultrasound modulate dendritic cells antigen presentation.  Nano Today,      [PMID:] [10.1016/j.nantod.2024.102402]
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63. Shi-Si Li, Jun-Lin Pan, Xi-Long Chen, Jing Xu, Zi-Long Li, Chunzu Cheng.  (2024)  Synthesis of long-chain aliphatic poly(β-thioester)s via thiol-Michael polyaddition and their applications in noble metal recovery and information encryption.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2024.113290]
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65. Xiaoqing Liu, Pengxiang Hao, Wenliang Wang, Guanying Guo, Congcong Wu, Rifang Ge.  (2025)  Development and Characterization of a Poly(Amino Acid)-Based pH-Responsive Dual-Mode Antibacterial Nanoparticles Dental Restorative Resin.  JOURNAL OF APPLIED POLYMER SCIENCE,      [PMID:] [10.1002/app.57570]
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68. Chao Zhou, Weina Hao, Jiapei Yao, Tianjun Zhu, Mengdi Sun, Yaojun Lu, Liangliang Wang, Xindie Zhou, Jia Ling Celestine Loh.  (2024)  Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis treatment.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39662575] [10.1016/j.ijbiomac.2024.138610]
69. Lili Sun, Haoyi Niu, Yuqiong Wu, Shiyan Dong, Xuefeng Li, Betty Y.S. Kim, Changsheng Liu, Yifan Ma, Wen Jiang, Yuan Yuan.  (2024)  Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification.  Bioactive Materials,      [PMID:38327823] [10.1016/j.bioactmat.2024.01.019]
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72. Lei Feng, Liugen Xu, Junhao Wen, Minghai Zhao, Amjad Ali, Naushad Ahmad, Jianwei Lu, Li Guo.  (2025)  Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids.  Biomimetics,  10  (6): (368).  [PMID:40558337] [10.3390/biomimetics10060368]
73. Fawei He, Yunfei Cui, Xue Tang, Dongting Zhangsun, Sulan Luo, Yong Wu.  (2025)  Synthesis of the plant cyclotide cyO14 via the hydrazide strategy and investigation of its antibacterial and insecticidal activities.  PEPTIDES,      [PMID:40543849] [10.1016/j.peptides.2025.171423]
74. Hanqi Dong, Xinxin Ping, Yuzhen Zhou, Hui Wang, Xin Zhou, Lupeng Shao, Xiao Xiao, Weixing Li, Chao Wang, Zhe Ling.  (2025)  Nature-Inspired Nanocellulose/Lignin Janus Films via Layered Assembly: The Enhanced Strength, UV Resistance, and Photothermal Conversion.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.5c03814]
75. Meng Liu, Peng Jiang, Binghui Ruan, Yunfei Cui, Junjie Zhang, Yuxiu Ye, Dongting Zhangsun, Sulan Luo, Yong Wu.  (2026)  Rational β-turn engineering of a disulfide-free β-hairpin-like antimicrobial peptide W2PG with enhanced stability, selectivity, and in vivo efficacy.  BIOORGANIC CHEMISTRY,      [PMID:41690116] [10.1016/j.bioorg.2026.109612]
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