Eculizumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, Human IgG2+Human IgG4, INHIBITOR of Complement C5 inhibitor, INHIBITOR of Complement C5 inhibitor

CAS: 219685-50-4 Cat. No.: Ab170870

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Human, Mouse

Isotype

Human IgG2+Human IgG4

Conjugation

Unconjugated

Overview

Eculizumab (anti-Complement C5) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab (anti-Complement C5) inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab (anti-Complement C5) has the potential for haemolysis research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Eculizumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, Human IgG2+Human IgG4, INHIBITOR of Complement C5 inhibitor

Synonyms

Anaphylatoxin C5a analog antibody | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody | C5 antibody | C5a anaphylatoxin antibody | C5a antibody | C5b antibody | CO5_HUMAN antibody | Complement C5 alpha'' chain antibody | Complemen

Specifications & Purity

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Host species

Human

Specificity

C5

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Action Type

INHIBITOR

Mechanism of action

INHIBITOR of Complement C5 inhibitor

Isotype

Human IgG2+Human IgG4

Light Chain Type

kappa

SDS-PAGE

26.1 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 165.6 kDa, under non-reducing conditions.

Purification Method

Protein A purified

Purity

>95%

Concentration

See COA

CAS

219685-50-4

Storage and Shipping

Shape

Liquid

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

SEC: Eculizumab (anti-Complement C5) (Ab170870)

Eculizumab (anti-Complement C5) (Ab170870) - SEC
The purity of Eculizumab (anti-Complement C5) (Ab170870) is more than 95% verified by HPLC.

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Leucine and derivatives N-carbamoyl-alpha amino acids and derivatives N-acyl-alpha amino acids Tryptamines and derivatives Alpha amino acid amides Indolecarboxylic acids 3-alkylindoles Piperidinecarboxamides Pyrrole carboxylic acids and derivatives Medium-chain fatty acids Amino fatty acids Aralkylamines Branched fatty acids Heterocyclic fatty acids Benzenoids Substituted pyrroles N-substituted carboxylic acid imides N-acyl amines Heteroaromatic compounds Dicarboximides Ureas Amino acids Carboxylic acids Azacyclic compounds Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Monoalkylamines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-dipeptide - Leucine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-carbamoyl-alpha-amino acid or derivatives - Alpha-amino acid amide - Indolecarboxylic acid - Indolecarboxylic acid derivative - Triptan - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - 1-piperidinecarboxamide - Piperidinecarboxamide - Medium-chain fatty acid - Pyrrole-1-carboxylic acid or derivatives - Heterocyclic fatty acid - Branched fatty acid - Aralkylamine - Amino fatty acid - N-acyl-amine - Carboxylic acid imide, n-substituted - Fatty acyl - Fatty acid - Benzenoid - Piperidine - Substituted pyrrole - Dicarboximide - Carboxylic acid imide - Heteroaromatic compound - Pyrrole - Urea - Amino acid or derivatives - Carbonic acid derivative - Amino acid - Organoheterocyclic compound - Carboxylic acid - Azacycle - Monocarboxylic acid or derivatives - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Amine - Primary aliphatic amine - Hydrocarbon derivative - Primary amine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

C5 Tclin Complement C5 (0 Activities)

Discover Target: C5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action