1-(2-Methoxy-5-methylphenyl)thiourea: Lab Handling Guide

1-(2-Methoxy-5-methylphenyl)thiourea is an aryl-substituted thiourea derivative (SKU N698906) used as a versatile building block and reagent in organic synthesis, medicinal chemistry, and heterocyclic compound preparation.

Product Name

1-(2-Methoxy-5-methylphenyl)thiourea

SKU

N698906

Chemical Class

Aryl thiourea derivative

Core Functional Group

Thiourea (–NH–C(=S)–NH₂)

Typical Applications

Organic synthesis building block, heterocyclic chemistry, medicinal chemistry research

Storage Recommendation

Store in a cool, dry, well-ventilated area away from oxidizing agents and moisture

Chemical Identity and Properties

1-(2-Methoxy-5-methylphenyl)thiourea is an aryl thiourea compound featuring a 2-methoxy-5-methylphenyl substituent on the nitrogen atom of the thiourea scaffold. Thioureas are well-established in organic chemistry as bifunctional molecules capable of acting as hydrogen-bond donors and acceptors, making them valuable in catalysis, coordination chemistry, and pharmaceutical research.

The methoxy group at the ortho position and the methyl group at the para position of the phenyl ring introduce steric and electronic modifications that influence the compound's reactivity and solubility profile. Researchers should consult the certificate of analysis (CoA) provided with SKU N698906 for confirmed purity, melting point, and spectroscopic data specific to the supplied lot.

Handling and Safety Guidelines

As with all thiourea-containing compounds, appropriate laboratory precautions must be observed when working with 1-(2-Methoxy-5-methylphenyl)thiourea. Operators should wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and a laboratory coat. Work should be performed in a fume hood to minimise inhalation exposure to dust or vapours.

Avoid contact with skin, eyes, and mucous membranes. In the event of skin or eye contact, flush the affected area immediately with copious amounts of water and seek medical advice if irritation persists. Do not ingest the compound. Wash hands thoroughly after handling.

Thiourea derivatives may present a risk of irritation to skin, eyes, and the respiratory tract. Always consult the Safety Data Sheet (SDS) for SKU N698906 before use. Dispose of waste in accordance with local, regional, and national environmental regulations.

Storage and Stability

Store 1-(2-Methoxy-5-methylphenyl)thiourea in a tightly sealed container in a cool, dry, and well-ventilated location. Keep away from incompatible materials, including strong oxidising agents, strong acids, and strong bases, which may decompose the thiourea functional group.

Protect the compound from moisture and direct light exposure to maintain integrity over the storage period. When not in use, reseal the original container promptly. Lot-specific stability information and recommended shelf life are detailed in the CoA accompanying SKU N698906.

Typical Research Applications

Aryl thioureas, including 1-(2-Methoxy-5-methylphenyl)thiourea, serve as important intermediates in the synthesis of benzimidazole-2-thiones, thiadiazines, and other sulfur-containing heterocycles. These heterocyclic products are of broad interest in medicinal chemistry due to their reported biological activities.

Thiourea derivatives are also employed as ligands in coordination chemistry for the preparation of metal complexes, and as organocatalysts or co-catalysts in asymmetric synthesis, where their hydrogen-bonding capacity is exploited to activate electrophilic substrates. Researchers exploring structure-activity relationships in drug discovery may use aryl thioureas as privileged scaffolds for library synthesis.

Quality and Ordering Information

1-(2-Methoxy-5-methylphenyl)thiourea is available from Aladdin Scientific under SKU N698906. Each lot is supplied with a Certificate of Analysis confirming identity, purity, and key physicochemical parameters. Researchers requiring specific purity grades or custom quantities are encouraged to contact Aladdin Scientific's technical support team.

For procurement teams, standard ordering can be completed through the Aladdin Scientific online portal using SKU N698906. Please refer to current pricing, availability, and shipping conditions on the product page or contact your regional Aladdin Scientific representative.

Frequently asked questions

What is 1-(2-Methoxy-5-methylphenyl)thiourea used for in research?

This compound is primarily used as a synthetic building block for the preparation of sulfur-containing heterocycles such as benzimidazole-2-thiones and thiadiazines, which are of interest in medicinal chemistry. It may also serve as a ligand in coordination chemistry or as a hydrogen-bond-donor organocatalyst in asymmetric synthesis.

How should 1-(2-Methoxy-5-methylphenyl)thiourea (N698906) be stored?

Store the compound in a tightly sealed container in a cool, dry, and well-ventilated area, protected from moisture, direct light, strong oxidising agents, strong acids, and strong bases. Refer to the CoA and SDS supplied with the product for lot-specific guidance.

What personal protective equipment (PPE) is recommended when handling this compound?

At minimum, wear chemical-resistant gloves, safety goggles, and a laboratory coat. Conduct all manipulations in a fume hood to prevent inhalation of dust or vapours. Consult the SDS for SKU N698906 for complete hazard and PPE guidance before beginning work.

Where can I obtain the Certificate of Analysis (CoA) for N698906?

The Certificate of Analysis for SKU N698906 is typically supplied with the product shipment and may also be available for download on the Aladdin Scientific product page using the specific lot number. Contact Aladdin Scientific customer service if you require further assistance locating your lot CoA.

References

1. General reference: Scheme of thiourea chemistry and applications in heterocyclic synthesis — standard organic chemistry textbooks (e.g., March's Advanced Organic Chemistry).
2. General reference: Thiourea organocatalysis and hydrogen-bond donor catalysis — review literature in chemical synthesis and asymmetric catalysis.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.