1-(2-Methoxyphenyl)propan-2-ol: Properties & Lab Use FAQ

1-(2-Methoxyphenyl)propan-2-ol is a secondary benzylic alcohol bearing an ortho-methoxy substituent on the phenyl ring, making it a versatile chiral building block and intermediate in organic synthesis research.

IUPAC Name

1-(2-Methoxyphenyl)propan-2-ol

Functional Groups

Secondary alcohol, aryl ether (methoxy)

Structural Feature

Ortho-methoxy substituted phenylpropanol; contains one chiral center at C-2

Compound Class

Guaiacol-derived secondary benzylic alcohol

Typical Research Use

Chiral synthesis intermediate, asymmetric reduction substrate, pharmaceutical building block

SKU

P698153

Chemical Identity and Structure

1-(2-Methoxyphenyl)propan-2-ol belongs to the class of aryl-substituted secondary alcohols. Its molecular framework consists of a propan-2-ol chain attached at C-1 to a phenyl ring that carries a methoxy group at the ortho (2-) position. This ortho-methoxy motif is characteristic of guaiacol-derived compounds and imparts distinct steric and electronic properties compared to meta- or para-substituted analogues.

The molecule contains a single chiral center at C-2 of the propanol chain, meaning it can exist as a pair of enantiomers [(R) and (S)]. Researchers should confirm whether a racemic mixture or a specific enantiomer is required for their application, as stereochemical purity can significantly influence biological or catalytic outcomes.

Handling, Storage, and Safety

As with most secondary benzylic alcohols, 1-(2-Methoxyphenyl)propan-2-ol should be handled in a well-ventilated fume hood using appropriate personal protective equipment, including nitrile gloves, safety glasses, and a laboratory coat. Avoid inhalation of vapors and contact with skin or eyes.

For storage, the compound should be kept in a tightly sealed container away from heat, direct sunlight, and strong oxidizing agents. Refrigerated storage (2–8 °C) in a dry environment is generally recommended to maintain chemical stability over extended periods, though users should consult the product-specific Safety Data Sheet (SDS) provided by Aladdin Scientific for authoritative guidance.

Waste disposal should follow local and institutional regulations for organic solvent waste. The SDS should be reviewed before first use for full hazard classification information.

Research and Synthetic Applications

1-(2-Methoxyphenyl)propan-2-ol serves primarily as a chiral building block and synthetic intermediate in organic chemistry. Its secondary alcohol functionality makes it amenable to a wide range of transformations, including oxidation to the corresponding ketone, esterification, etherification, and participation in asymmetric reactions.

The ortho-methoxy group can engage in directing effects during electrophilic aromatic substitution and may facilitate chelation-controlled reactions in metal-catalyzed processes. Researchers investigating asymmetric synthesis, pharmaceutical intermediate preparation, or structure–activity relationship (SAR) studies may find this compound particularly useful as a model substrate or precursor.

It may also appear as an intermediate or reference standard in the synthesis of bioactive molecules, including compounds with central nervous system (CNS) activity given the structural resemblance to certain phenylpropanolamine-type scaffolds, though specific biological data should be verified in the primary literature.

Purity, Grade, and Quality Considerations

For synthetic applications, a high purity grade is generally preferred to minimize side reactions caused by impurities. Researchers should confirm the purity specification (e.g., ≥95% or ≥98% by GC or HPLC) and request a Certificate of Analysis (CoA) when ordering from Aladdin Scientific (SKU: P698153).

If enantiopure material is required, users should verify the enantiomeric excess (ee) value stated on the CoA, as standard catalogue lots may be supplied as racemates. For chiral applications, additional enantioselective resolution or asymmetric synthesis steps may be necessary.

Lot-to-lot consistency is important for reproducible research results. Aladdin Scientific provides CoA documentation to support quality assurance requirements in both academic and industrial laboratory settings.

Frequently asked questions

What is 1-(2-Methoxyphenyl)propan-2-ol used for in research?

It is primarily used as a chiral synthetic intermediate and building block in organic chemistry. Its secondary alcohol group enables diverse transformations such as oxidation, esterification, and asymmetric reactions, while the ortho-methoxy group provides useful directing and chelation properties in catalytic processes.

Is 1-(2-Methoxyphenyl)propan-2-ol supplied as a racemate or as a single enantiomer?

Standard catalogue lots are typically supplied as racemic mixtures unless otherwise specified. Researchers requiring enantiopure material should contact Aladdin Scientific to confirm the stereochemical specification and enantiomeric excess (ee) value stated on the current Certificate of Analysis for SKU P698153.

What are the recommended storage conditions for this compound?

The compound should be stored in a tightly sealed container in a cool, dry environment away from light and strong oxidizing agents. Refrigerated storage at 2–8 °C is generally advisable to maintain long-term stability. Always refer to the product SDS for authoritative storage and safety guidance.

How can I confirm the purity of the 1-(2-Methoxyphenyl)propan-2-ol I receive?

A Certificate of Analysis (CoA) is available for each lot of SKU P698153 and details purity as determined by GC or HPLC analysis. You may request the CoA from Aladdin Scientific at the time of ordering or by contacting customer support with your lot number.

What safety precautions should be taken when handling this compound?

Handle in a well-ventilated fume hood wearing nitrile gloves, safety glasses, and a lab coat. Avoid inhalation of vapors and skin or eye contact. Dispose of waste according to local organic solvent regulations. Review the full SDS before first use for complete hazard and first-aid information.

References

1. Aladdin Scientific Product Page: 1-(2-Methoxyphenyl)propan-2-ol, SKU P698153. Aladdin Scientific Corp.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. General reference for secondary alcohol transformations.
3. Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry. Oxford University Press. Reference for aryl ether directing effects and chiral center chemistry.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.