Amide

Amides are among the most common functional groups in drug molecules. They can provide hydrogen-bonding interactions, connect different structural fragments, and help molecules maintain specific conformations through their relatively strong planarity. However, an amide is not always the optimal ...

The amide bond is one of the most commonly used chemical bonds in organic synthesis. The methods used to form this important functional group are often superchemically stoichiometric, leading to significant waste in the process. These factors led the American Chemical Society Green Chemistry ...