FGF21

Obesity and related metabolic diseases are characterized not only by increased energy intake and fat storage but also by abnormalities in hepatic glucose and lipid metabolism, substrate utilization, and amino acid homeostasis. GCGR is an important Class B1 GPCR that regulates hepatic substrate ...

Metabolic dysfunction-associated steatohepatitis is jointly driven by hepatic fat accumulation, lipotoxicity, insulin resistance, inflammation, and fibrosis. Targeting lipid metabolism, nuclear receptors, incretin pathways, and FGF signaling has become a major direction in drug development.

Mitochondrial functional disturbance can activate a series of stress signals to restore energy metabolism, protein homeostasis, and redox balance. Decreased membrane potential, impaired respiratory chain function, defective protein import, or abnormal mitochondrial proteostasis can induce ...