p53 is a central transcriptional regulatory protein in the tumor-suppressor network. Its functions extend beyond DNA damage responses, cell-cycle arrest, and apoptosis to amino acid metabolism, redox homeostasis, and lipid oxidation. Ferroptosis is a form of regulated cell death driven by ...
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GPX4
Techniques for detecting, quantifying and localizing antigens and antibodies — ELISA, Western blotting, immunohistochemistry and flow cytometry. Below are the protocols, FAQs and technical articles in our knowledge base tagged with this topic.
4 resources · protocols, FAQs & articles
Intracellular H₂O₂ and lipid peroxides require the coordinated action of multiple antioxidant enzyme systems for clearance. Among them, Glutathione Peroxidase (GPx), Catalase (CAT), and Peroxiredoxin (PRDX) control peroxides in different substrate and subcellular environments. GPX4 further ...
Ferroptosis is a form of metabolic cell death jointly driven by disruption of iron homeostasis, accumulation of membrane lipid peroxidation, and failure of lipid antioxidant defense systems.
The GPX family constitutes an important enzymatic system in the regulation of cellular redox homeostasis and participates in peroxide clearance, termination of lipid peroxidation, maintenance of membrane homeostasis, and control of stress-induced injury. Different members exhibit clear ...
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Techniques often explored alongside immunological experiments.