Halogenation Reagents

The pentafluorosulfanyl (SF₅) group, as a unique fluorine-containing functional group, has demonstrated broad application prospects in medicinal chemistry, materials science, and other fields due to its excellent chemical stability, high electronegativity, and lipophilicity. In recent years, ...

Pentafluorosulfanyl chloride (SF₅Cl), a pivotal reagent for direct pentafluorosulfanylation, has seen remarkable advancements in synthesis and handling safety. Key developments include

In 2015, the Dolbier group reported a method where phenylacetylene is used as the substrate, reacting with SF₅Cl under the catalysis of triethylborane (BEt₃) to generate a chlorinated pentafluorosulfanylated intermediate (189).

In the field of organic chemistry, halogenation reactions and their products - halogenation compounds - do play a crucial role. These reactions not only enrich the toolbox of organic synthesis, but also greatly expand the application range of halogenation compounds in complex molecular ...

Chloramine-T is a source of electrophilic chlorine. In water, chloramine-T is decomposed to yield hypochlorite, which acts as a disinfectant, and the sulfonamide moiety, which inhibits bacterial grow due to the similarity with para-aminobenzoic acid (a bacterial metabolite). Chloramine-T can ...

The use of chloramine-B as the oxidant and KI or NaBr as the halogen source enables a direct oxidative halogenation of terminal alkynes to provide synthetically valuable 1-iodoalkynes and 1-bromoalkynes in very good yields under mild reaction conditions.