Methionine Cycle

S-Adenosylmethionine is one of the most important activated methyl donors in cells and is widely involved in methyl-transfer reactions affecting DNA, RNA, proteins, lipids, and multiple classes of small molecules. Current understanding of methylation regulation has expanded from the level of ...

MAT catalyzes the conversion of methionine and ATP into S-adenosylmethionine (SAM). SAM is not only one of the most central active methyl donors in cells, but also lies at the intersection of one-carbon metabolism, epigenetic regulation, and stress adaptation. As mechanisms involving MAT1A/MAT2A ...

One-carbon metabolism is not merely a matter of folate nutrition, but rather a metabolism-signaling integrated system jointly constituted by the folate cycle, the methionine cycle, and the transsulfuration pathway. On the one hand, this system sustains nucleic acid synthesis and methylation ...