Protein degradation

RAS mutations drive many tumors, including pancreatic cancer, colorectal cancer, and lung cancer. However, RAS was long considered difficult to drug because of its shallow structural pockets and tight GTP binding. The emergence of RAS(ON) inhibitors, molecular glues, and PROTACs has shifted RAS ...

Endopeptidases and exopeptidases act on internal and terminal regions of peptide chains, respectively. They are important enzyme classes in protein degradation, peptide processing, antigen presentation, cell death, and disease microenvironment research. The two differ clearly in substrate level, ...

Aminopeptidases are a class of exopeptidases that act on the N-terminus of peptides and sequentially remove N-terminal amino acid residues. They participate in protein degradation, antigen peptide processing, peptide signal regulation, and disease development. The research focus is to analyze ...

PROTACs (PROteolysis-TArgeting Chimeras) are heterobifunctional small molecules that induce targeted protein degradation. Each PROTAC molecule contains two distinct ligands: one is a target protein ligand that binds specifically to the intracellular protein of interest (POI), and the other is a ...

Nucleic acid extraction is a fundamental process in molecular diagnostics, genetic sequencing, and other related fields. Its core goal is to obtain high-purity, high-integrity nucleic acids. Due to their specificity, RNase A and Proteinase K have become critical auxiliary tools for removing ...