1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
The complete structure of an unknown glycoside comprises multiple levels of information, including the molecular formula, aglycone structure, types and numbers of sugars, linkage position between the sugar and aglycone, sugar-chain linkage sequence, and anomeric configurations. High-resolution ...
Drug molecules bind to proteins in an aqueous environment. Before binding, polar groups on the drug surface, such as hydroxyl groups, carbonyl groups, ether oxygens, and heterocyclic nitrogens, interact with surrounding water molecules, while water molecules with different positions and ...
The chemical composition of natural products may continue to change after plant materials are harvested. Cutting and pulverization alter tissue integrity; moisture, temperature, and pH affect endogenous enzyme activity; and drying and heating can further alter enzymatic reactions, tissue ...
In glycosides, the anomeric carbon of the sugar can be linked to the non-sugar moiety through an oxygen, nitrogen, or sulfur atom, or it can form a direct carbon–carbon bond with a carbon atom of the aglycone. The mode of linkage alters the electronic structure of the anomeric reaction center, ...
On August 19, 2026, Merck and Moderna announced positive topline results from a Phase III clinical trial in melanoma. The study evaluated a patient-specific messenger RNA (mRNA) neoantigen therapy in combination with pembrolizumab. The therapy was previously designated mRNA-4157/V940 during ...
When natural products form glycosides with sugars, the properties of the resulting molecules often change accordingly. The introduction of glycosyl groups not only increases molecular weight but also alters the number and distribution of oxygen-containing functional groups, hydrogen-bonding ...
Oxygen in lignan molecules can occur in different functional groups, including phenolic hydroxyls, aryl methyl ethers, methylenedioxy groups, aliphatic alcohols, carbonyl groups, lactones, and glycosides. When the functional state of an oxygen atom changes, the manner in which its lone pairs ...
In 2016, two independent studies published in Science found that cancer cells deficient in methylthioadenosine phosphorylase (MTAP) were more sensitive to partial depletion of protein arginine methyltransferase 5 (PRMT5).[1,2] This finding emerged from large-scale functional genomic screens and ...
Extracellular leucine-rich repeat (LRR) structures are widely present in secreted proteins, extracellular matrix proteins, and transmembrane receptors and constitute an important structural basis for extracellular molecular recognition. Proteins such as LRG1, Slit, SLRPs, TLRs, and LGRs can use ...
