1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
The Simmons–Smith reaction constructs cyclopropanes by transferring a methylene group to an alkene carbon–carbon double bond. In the classical reaction, diiodomethane (CH₂I₂) and a zinc–copper couple generate a zinc carbenoid reagent that transfers a CH₂ unit to the alkene, generally ...
The amide group possesses both hydrogen-bond donor and hydrogen-bond acceptor capabilities, together with well-defined local conformational characteristics. Resonance restricts rotation about the amide C—N bond relative to an ordinary C—N single bond, and the amide linkage generally exhibits ...
Rotary evaporators are commonly used for post-reaction processing, removing volatile solvents through reduced pressure, heating, rotation, and condensation. Chen, Wang, and Zhang investigated the factors affecting the time required to remove high-boiling solvents using a rotary evaporator and ...
The International Union of Pure and Applied Chemistry (IUPAC) defines quinones as compounds having a fully conjugated cyclic dione structure. Formally, they may be regarded as being derived from aromatic compounds by conversion of an even number of —CH= units into —C(=O)— units, ...
Metallaphotoredox catalysis combines photoredox processes with transition-metal catalysis. After absorbing visible light, the photocatalyst participates in single-electron transfer, generating radicals that subsequently enter bond-forming processes catalyzed by transition metals such as nickel. ...
On August 24, 2026, Japan’s Ministry of Health, Labour and Welfare approved bepirovirsen (development code GSK3228836, commonly abbreviated as GSK836), developed by GSK and marketed under the brand name Hibsago, for functional cure in eligible adults with persistent hepatitis B virus ...
In an intramolecular [2+2] photocycloaddition, two alkenes are connected by a tether. Depending on how the reactive carbon atoms of the two alkenes are paired, two types of regiochemical connectivity can be formed: straight and crossed.
LY3509754 is a small-molecule inhibitor of interleukin-17A (IL-17A). Its synthesis requires a key intermediate containing a 4,4-difluorocyclohexyl group, a chiral amino substituent, and an α-bromoketone moiety. In a 2025 process development study, 110 kg of this α-bromoketone intermediate was ...
In 2014, Tellis, Primer, and Molander reported a photoredox/nickel dual-catalytic cross-coupling involving organotrifluoroborates. Conventional organoboron cross-coupling relies on a two-electron transmetalation process, whereas transmetalation of C(sp³) organoboron reagents is often relatively ...
