It is a long-term goal for biomedical researchers to develop efficient and reliable methods to make accurate and targeted changes in the genome of living cells. In recent years, a new tool based on bacterial CRISPR-associated protein-9 nuclease (Cas9) from Streptococcus pyogenes has aroused ...
In the field of tissue engineering and regenerative medicine, the design of biomaterial scaffolds that can reproduce the complex extracellular nature of living tissues in three dimensions is a challenging requirement. Hydrogels are a widely studied and developed class of synthetic extracellular ...
The Janus kinase (JAK) signal transduction and transcriptional activator (STAT) pathway plays a key role in the signaling of a large number of cytokines and growth factors. These cytokines and growth factors are responsible for a variety of cellular functions, including proliferation, growth, ...
Trifluoromethyl is one of the important chemical groups in the field of medicinal chemistry, and is widely used in bioactive molecules because of its high lipid solubility, excellent metabolic stability, high electronegativity and good bioavailability. The introduction of trifluoromethyl in drug ...
Biotechnology fields such as tissue engineering and drug delivery continue to grow with the increasing demand for diverse functional biomaterials. For decades, research in polymeric biomaterials has focused on testing the biocompatibility of polymers developed for other applications or their ...
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