1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Over the years, oligonucleotide synthesis methods have evolved: from Michelson and Todd's early H-phosphonate and phosphoric acid triglyceride methods, and Khorana's phosphodiester method in the 1950s, to the revisiting of the phosphoric acid triglyceride method in the 1960s and the phosphite ...
Nucleic acid electrophoresis is used in many molecular biology research applications to test experimental results, and sometimes to isolate and purify samples for subsequent applications. Therefore, the application of conventional nucleic acid electrophoresis can generally be divided into ...
At its inception, graphene was essentially a game for physicists. It was difficult to synthesize sufficient quantities of high-quality graphene, and it was not until researchers prepared monolayer graphene by simple mechanical peeling of graphite using tape that this new material with excellent ...
Artificial synthesis of nucleic acids has now become an important technique in biochemistry and a great deal of technical experience has been accumulated today. The key to the efficient synthesis of nucleic acids lies in the proper protection and deprotection of functional groups during the ...
The nucleic acid electrophoresis workflow requires the execution of several steps, each of which may affect the result of nucleic acid separation. This page discusses 7 additional considerations related to samples, reagents, and operating parameters, including: Nucleic acid sequence and ...
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and redox transition metal ions such as iron, copper and cadmium.
The epidermal growth factor (EGF) family is a group of structurally related proteins that regulate cell proliferation, migration and differentiation through tyrosine kinase receptors on target cells. EGF receptors have a cytoplasmic tyrosine kinase domain, a transmembrane domain, and an ...
Bioorthogonal chemistry refers to a series of reactions that occur in a biological environment without affecting biomolecules or interfering with biochemical processes. For this purpose, the reaction must meet the following requirements: fast, efficient, and specific. • pH: The reaction must ...
In neoplastic cells, the de novo synthesis of nucleotides is responsible for maintaining sufficient nucleotide libraries to support DNA replication and RNA production. The metabolic pathways that support nucleotide production are dependent on metabolic intermediates provided by glycolysis and ...
