FIPI - ≥98%(HPLC) , CAS No.1781834-93-2

CAS: 1781834-93-2 Cat. No.: F288161 Formula: C₂₃H₂₄FN₅O₂•HCl Molecular Weight: 457.9 PubChem CID: 90488864

GRADE & PURITY ≥98%(HPLC)

Synonyms

N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride | FIPI hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product description：

FIPI is an effective and selective phospholipase D inhibitor that reduces mercury-induced lipid signaling and thus protects aortic endothelial cells from cytotoxicity.

Specifications

Synonyms

N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride | FIPI hydrochloride

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Potent phosholipase D (PLD) inhibitor (IC50values are 20 and 25 nM for PLD2and PLD1respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 528764461
• Canonical Smiles: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F.Cl
• IUPAC Name: 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide;hydrochloride
• InChIKey: BNMQCDOCYPGJJD-UHFFFAOYSA-N
• INCHI: 1S/C23H24FN5O2.ClH/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31;/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31);1H
• Isomeric SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F.Cl
• PubChem CID: 90488864
• Molecular Weight: 457.9

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 22.9, Max Conc. mM: 50