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Hydroxypropylmethylcellulose - Substitution type 2208, viscosity: 100000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% , CAS No.9004-65-3

CAS: 9004-65-3 Cat. No.: H108826 EC Number: 618-389-6 PubChem CID: 206257985
252 Citations COA
Hydroxypropylmethylcellulose - Substitution type 2208, viscosity: 100000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% CAS No(9004-65-3) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Substitution type 2208, viscosity: 100000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12%
Synonyms
HPMC MHPC Hydroxypropyl Methyl Cellulose
Storage
Room temperature
Shipped In
Normal
★
Size
Germany (EU)
USA*
Price
Qty
25g
H108826-25g
—
1 In stock
€8.59
100g
H108826-100g
—
3 In stock

€21.61

€25.95
Save €4.34 (16.72%)
500g
H108826-500g
5 In stock
1 In stock

€63.26

€86.69
Save €23.43 (27.03%)
Enter a quantity for the sizes you want to add.
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data Certificates（CoA,COO,BSE/TSE and Analysis Chart) Documents & Articles Citations of This Product Solution Calculators Reviews
🧪
Why this grade

Substitution type 2208, viscosity: 100000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 252 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

(Hydroxypropyl)methylcellulose (HPMC) is a water-soluble polymer derived from cellulose. This polysaccharide forms colloids when dissolved in water. HPMC is a hydrocolloid produced artificially from natural substances. It consists of 28-30% methoxyl content and 7-12% of hydroxypropoxyl content.

Application：

(Hydroxypropyl)methyl cellulose (HPMC) has been used:
as a viscosity modifier in the preparation of printable ink
as a viscosifier in the preparation of hydroxyapatite (HAP) suspension
in the preparation of HPMC gels and composite gels
Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Specifications

Synonyms
HPMC MHPC Hydroxypropyl Methyl Cellulose
Specifications & Purity
Substitution type 2208, viscosity: 100000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12%
Biochemical and Physiological Mechanisms
(Hydroxypropyl)methylcelluloses (HPMCs) act as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers. Additionally, solutions of these polymers show thermal gelation properties. They are generally used as binders, thickeners, film
Storage
Room temperature
Shipped In
Normal
Names and Identifiers
Pubchem Sid
508815931
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/508815931
WGK Germany
1
PubChem CID
206257985

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

29 results found

Lot NumberCertificate TypeDateItem
A2310338Certificate of AnalysisSep 22, 2026 H108826
A2310339Certificate of AnalysisSep 22, 2026 H108826
C2627436Certificate of AnalysisFeb 03, 2026 H108826
C2627433Certificate of AnalysisFeb 03, 2026 H108826
B2625591Certificate of AnalysisFeb 03, 2026 H108826
B2625592Certificate of AnalysisFeb 03, 2026 H108826
C2603647Certificate of AnalysisFeb 03, 2026 H108826
C2627427Certificate of AnalysisFeb 03, 2026 H108826
C2627430Certificate of AnalysisFeb 03, 2026 H108826
H2512294Certificate of AnalysisJun 07, 2025 H108826
H2512295Certificate of AnalysisJun 07, 2025 H108826
H2512497Certificate of AnalysisJun 07, 2025 H108826
L2511094Certificate of AnalysisJun 07, 2025 H108826
L2423207Certificate of AnalysisDec 09, 2024 H108826
L2423208Certificate of AnalysisDec 09, 2024 H108826
L2423209Certificate of AnalysisDec 09, 2024 H108826
D2416301Certificate of AnalysisMar 14, 2024 H108826
H2321123Certificate of AnalysisNov 08, 2022 H108826
E2414025Certificate of AnalysisNov 08, 2022 H108826
D2507112Certificate of AnalysisNov 08, 2022 H108826
A2310328Certificate of AnalysisNov 08, 2022 H108826
A2310327Certificate of AnalysisNov 08, 2022 H108826
F2426235Certificate of AnalysisJul 28, 2022 H108826
I2202602Certificate of AnalysisJul 28, 2022 H108826
I2202637Certificate of AnalysisJul 28, 2022 H108826
I2405066Certificate of AnalysisJul 28, 2022 H108826
A2206761Certificate of AnalysisDec 13, 2021 H108826
A2206841Certificate of AnalysisDec 13, 2021 H108826
A2206768Certificate of AnalysisDec 13, 2021 H108826
Documents & Articles
A Practical Guide to Fragrance Compositions: Turning a Black-Box Formula into an Engineerable System—Compatibility, Stability, Controlled Release, Traceability, and Selection
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Fragrance Fragrance composition Fragrance base
Microcrystalline Cellulose (MCC): A Comprehensive Primer and Selection Guide—Structural Features, Key Performance Metrics, and Application Scenarios
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Microcrystalline Cellulose MCC
Understanding Hydrophilic Polymers in Aqueous Systems: Hydration Mechanisms, Structural Knobs, and Task-Oriented Selection Guide (Including Tables 1–3)
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Polymer Biomedical materials Hydrophilicity hydrophilic polymers
Biomedical Polymer Insights: Role-Based Task Map, Six Key Material Levers, and a Risk-Driven Evidence Chain (including the Product Navigation Guide and Product Tables 1–3)
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Polymer Biomedical polymer Biomedical
Functional Framework of Starch Metabolism-Related Enzymes in Food Science Research and Mechanistic Analysis of Quality Regulation
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
α-amylase Rheology Starch Metabolism-Related Enzymes Food Science Research Quality-Regulation Mechanisms Glucoamylase Debranching Enzymes Transglycosylases Staling Digestive Properties
Injectable Thermosensitive Gels: Gelation Behavior, Rheological Properties, and Drug Release Characteristics
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Chitosan injectable thermosensitive gel Pluronic F-127 PLGA-PEG-PLGA gelation behavior rheological properties drug release characteristics in situ gelation
Waterborne Resin Technology Explained: Waterborne Forms, Performance Balance, and a Technology Map
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Ink Paint Film-forming resin Adhesive Waterborne Resin
Waterborne Resin Application Guide: Formulation Synergy, Troubleshooting, and Technology Development Trends
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
resin Waterborne Resin Water-based paint
Why LABSA (Sulfonic Acid) Is Commonly Used in Household Cleaning Formulations: Neutralization Mechanism, Detergency Action, and Formulation Application Points
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Anionic Surfactant Surfactants Daily Chemical Industry
From Structure to Performance: Conditioning, Film-Forming, Thickening, and Chelating Applications of Functional Ingredients in Personal Care and Home Care
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Anionic Surfactant Daily chemical formula
From Structure to Rheology: How Carbomer Forms Gel Structures and Enables Thickening, Suspension, and Auxiliary Emulsion Stabilization
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Carbomer
Thickening, Suspension, Auxiliary Stabilization, and Agglomeration Mechanisms of Xanthan Gum in Personal Care Formulations: From Molecular Structure to Processing Applications
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Xanthan Gum
From Structure to Rheology: Thickening, Stabilization, and Selection Logic of Cellulose Ethers for Personal Care Applications
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Cellulose cosmetics linear polysaccharide
Structure, Properties, and Mechanisms of Powdered Fragrances and Fragrance Delivery Materials: Stability, Release Mechanisms, and Selection Logic
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Fragrance Powdered Fragrances
Analysis of the Production Process of Hydroxypropyl Methylcellulose (HPMC) for Putty: Understanding Differences in Substitution Structure and Gelation Temperature from High-Ratio and Low-Ratio Formulations
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
HPMC Neutral putty 821 putty Ordinary interior wall putty
Why Are Daily Chemical Products Prone to Viscosity Thinning in Summer? Core Mechanisms, Troubleshooting Methods, and Solutions
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Daily chemical products Return to thinning
Types, Mechanisms of Action, Key Quality Indicators, and Selection and Application of Common Cellulose Ethers in Wall Putty
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Wall Putty Cellulose Ether
Influencing Factors and Control Strategies for Blistering in Neutral Wall Putty: An Experimental Analysis Based on HPMC Dosage, Viscosity, and Ground Calcium Carbonate Fineness
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral Wall Putty Putty bubbles
How to Select Binding/Gel Materials for Neutral Wall Putty? A Comparison of Pregelatinized Starch, PVA, and Redispersible Polymer Powder Based on Four Application Trials
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
HPMC Neutral Wall Putty
Causes and Mechanism Analysis of Delamination During Sanding of Water-Resistant Putty
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Water-Resistant Putty
What Are the Differences Between Polyvinyl Alcohol 1788, 2488, and 2699? Understanding Workability, Bonding Strength, and Relative Water Resistance from the Perspective of Degree of Polymerization and Degree of Hydrolysis
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Paint Adhesive Water-soluble polymer materials Polymer materials
Why Do Rust Spots Appear on Neutral Wall Putty? Iron Sources, Moisture Migration, Oxidative Color Development, and Prevention Measures
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
Common Problems and Formulation Adjustment Strategies for Neutral Putty Under High Summer Temperatures
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
Differences and Application Selection of Cassava- and Corn-Based Pregelatinized Starch in Neutral Putty Formulations
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
The Role, Selection, Cracking Risk Analysis, and Dosage Control of Bentonite in Neutral Putty
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Neutral putty
What Is Direct Compression? Process Characteristics, Suitability Criteria, and Excipient Selection
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Direct Compression Wet granulation and tablet compression Dry granulation and tablet compression
Niacinamide Brightening Mechanisms and Formulation Design: Melanosome Transfer, pH Regulation, and Combination Strategies
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Niacinamide
Citations of This Product
How to Cite Aladdin Scientific Products? Citations Search
Solution Calculators
Reviews

Customer Reviews

📚 Citations by Application

Other applications141
Organic synthesis — reaction medium89
Controlled-release & nanoparticle carrier57
Topical & ophthalmic formulation12
Polymer synthesis & polymerization41
Extraction & workup solvent32
Industrial & non-pharma application20
Cell viability6
Cytotoxicity screening5
Drug / compound screening22
Nanoparticle / material biocompatibility6
Thickener / viscosity modifier12
Crystallization & recrystallization11
Film coating13
Electrochemistry & battery electrolyte15
Mucoadhesive formulation4
Spectroscopy sample preparation5
Chromatography (HPLC / GC / TLC)4
Tablet binder4
Cell proliferation3
Sustained-release matrix2
IC50 determination1
Stem cell research1
Cross-coupling reactions1
Emulsion formulation1
Food science applications1
View all 252 citations →
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Biochemical Assay Reagents (921) Cellulose Derivatives (3)

Related Products

Hydroxypropylmethylcellulose(HPMC) - Substitution type 2208, viscosity: 4000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% , CAS No.9004-65-3
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Hydroxypropylmethylcellulose - Type I, viscosity: 400mPa. s , CAS No.9004-65-3
Hydroxypropylmethylcellulose - 30mPa.s, Methoxy group: 28-30%; Hydroxypropyl group: 7.5-12% , CAS No.9004-65-3
Hydroxypropylmethylcellulose - type II，viscosity ：100mPa.s , CAS No.9004-65-3
Hydroxypropylmethylcellulose - Substitution type 2208, viscosity: 15000mPa. s, methoxy group: 19-24%; Hydroxypropyl group: 4.0-12% , CAS No.9004-65-3
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Hydroxypropylmethylcellulose - USP2910，2%viscosity ：3mPa.s,methoxyl：28-30%；hydroxyl：7.0-12% , CAS No.9004-65-3
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Hydroxypropylmethylcellulose - Substituted Type 2910, Viscosity: 4000 mPa·s, Methoxy: 28-30%; Hydroxypropyl: 7.0-12% , CAS No.9004-65-3
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