Microcrystalline Cellulose - ChP, JP, Ph.Eur., E 460(i), FCC, NF , CAS No.9004-34-6

CAS: 9004-34-6 Cat. No.: M489093 Formula: (C₆H₁₀O₅)_n EC Number: 232-674-9 PubChem CID: 16211032

GRADE & PURITY ChP, JP, Ph.Eur., E 460(i), FCC, NF

Synonyms

(5S)-6-(hydroxymethyl)-5-{[(2S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-2,3,4-triol | Diethylaminoethyl cellulose | Cellulosepulver | Express-Ion(TM) exchanger?? D free base, 60-130 mum | DEAE-CELLULOSE | EN300-381040 | (6S)-2-(HYDROXYMETHYL

Storage

Room temperature

Shipped In

Normal

Overview

Microcrystalline cellulose is very strong and chemically inert, so it is a very ideal carrier. API layered microcrystalline cellulose can be filled into capsules or pressed into tablets. They have a very tight particle size distribution, which can better control and improve the consistency of API release between batches. The uniformity of particle size minimizes the risk of packaging or tablet pressing, resulting in higher uniformity of API content. In addition, different APIs can be used in a variety of concentrates and combined with pellet core coating in a unit dose.

Product specifications

SKU	Average Particle Size by Laser Diffraction (µm)	Bulk Density (g/mL)	Main Application
M489093-01	15	max 0.26	Very fine grade, which gives a pleasant mouth feeling, masks bitter tastes and supports flavors.
M489093-02	65	0.26–0.31	Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility.
M489093-03	65	0.26-0.34	Same quality as grade 101/50M, but very low moisture content (< 1.5 %) for processing water-sensitive actives.
M489093-04	65	0.35-0.46	Same quality as grade 101, but increased bulk density and improved flow properties.
M489093-05	130	0.28-0.33	Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility.
M489093-06	130	0.30-0.36	Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives
M489093-07	130	0.35-0.50	Same quality to grade 102/90M, but increased bulk density and improved flow properties. Especially suited for high speed tableting and processing high density actives.
M489093-08	170/175	0.28-0.34	Coarse, DC-grade MCC.
M489093-09	180	0.30-0.36	Coarse grade MCC, combines good compactibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation – even when used with low concentrations of fine actives.
M489093-10	170	0.32-0.40	Same quality to grade 12, but very low moisture content (<1.5 %) for processing water-sensitive actives.
M489093-11	250	0.31-0.37	Large size MCC grade with excellent flow properties for a variety of direct compression formulations.
M489093-12	250	0.33-0.40	Same quality to grades 200/LP200, but very low moisture content (<1.5 %) for processing water-sensitive actives.
M489093-13	220	0.20-0.37	Coarse grained microcrystalline cellulose has good compressibility and adhesion, and good fluidity. Even for active ingredients with low content and fine particle size, tablets with good content uniformity and small differences in tablet weight can be obtained.

Benefits

1.High compactability,

2.Robust tablets with low friability,

3.High production yields,

4.Practically inert – compatible with most APIs,

5.Created from sustainable organic materials,

6.Contains no additives, impurities, or irradiated components,

7.Advanced carton packaging design for fast NIR identification.

Specifications

Synonyms

(5S)-6-(hydroxymethyl)-5-{[(2S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-2,3,4-triol | Diethylaminoethyl cellulose | Cellulosepulver | Express-Ion(TM) exchanger?? D free base, 60-130 mum | DEAE-CELLULOSE | EN300-381040 | (6S)-2-(HYDROXYMETHYL

Specifications & Purity

ChP, JP, Ph.Eur., E 460(i), FCC, NF

Storage

Room temperature

Shipped In

Normal

Grade

ChP, E 460(i), FCC, JP, NF, Ph.Eur.

Names and Identifiers

IUPAC Name

(6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol

InChIKey

GUBGYTABKSRVRQ-WFVLMXAXSA-N

INCHI

1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3?,4?,5?,6?,7?,8?,9?,10-,11?,12+/m1/s1

Isomeric SMILES

C(C1[C@H](C(C(C(O1)O)O)O)O[C@H]2C(C(C(C(O2)CO)O)O)O)O

WGK Germany

3

RTECS

FJ5691460

PubChem CID

16211032

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Glycosyl compounds
          • Level6 O-glycosyl compounds

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: O-glycosyl compounds
• Alternative Parents: Disaccharides Oxanes Secondary alcohols Hemiacetals Polyols Oxacyclic compounds Acetals Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: O-glycosyl compound - Disaccharide - Oxane - Secondary alcohol - Hemiacetal - Oxacycle - Organoheterocyclic compound - Polyol - Acetal - Hydrocarbon derivative - Primary alcohol - Alcohol - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Molecular Weight: 342.300 g/mol
• XLogP3: -4.700
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 342.116 Da
• Monoisotopic Mass: 342.116 Da
• Topological Polar Surface Area: 190.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 382.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 8
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Frequently Asked Questions

What does ChP mean?

ChP indicates that the material complies with the published monographs of the relevant pharmacopoeia (ChP). Specifications include identity, assay, impurity limits, residual solvents and other tests defined in the monograph. ChP-compliant material is suitable for pharmacopoeia-compliant pharmaceutical use, including pharmaceutical manufacturing, QC and regulatory submission.

How should this product be stored?

Store at room temperature.

What does JP mean?

JP indicates that the material complies with the published monographs of the relevant pharmacopoeia (JP). Specifications include identity, assay, impurity limits, residual solvents and other tests defined in the monograph. JP-compliant material is suitable for pharmacopoeia-compliant pharmaceutical use, including pharmaceutical manufacturing, QC and regulatory submission.

How is this product shipped?

This product ships under standard ambient conditions. No temperature-controlled packaging is required.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 9004-34-6, the molecular formula is (C6H10O5)n. InChIKey GUBGYTABKSRVRQ-WFVLMXAXSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.