Mito-TEMPO - Moligand™, ≥98% , CAS No.1334850-99-5

CAS: 1334850-99-5 Cat. No.: M414479 Formula: C₂₉H₃₆ClN₂O₂P Molecular Weight: 511

GRADE & PURITY Moligand™, ≥98%

Synonyms

1-​Piperidinyloxy,2,​2,​6,​6-​tetramethyl-​4-​[[2-​(triphenylphosphonio​)​acetyl]​amino]​-​,chloride (1:1) | [2,2,6,6-Tetramethyl-4-[2-(triphenylphosphonio)acetamido]-1-piperidinyl]oxidanyl Chloride

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

Mito-TEMPO Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.

Targets

RIP3 kinase

In vitro

Mito-TEMPO improves blastocyst development by superoxide reduction in porcine embryos in vitro.

In vivo

Mito-Tempo (MT) treatment inhibits APAP-induced RIP3 kinase expression, and RIP3-deficient mice shows caspase activation and apoptotic morphology in hepatocytes analogous to MT treatment.

Cell Research(from reference)

Cell lines：Porcine embryos 

Concentrations：0.1\u2009μM 

Specifications

Synonyms

1-​Piperidinyloxy,2,​2,​6,​6-​tetramethyl-​4-​[[2-​(triphenylphosphonio​)​acetyl]​amino]​-​,chloride (1:1) | [2,2,6,6-Tetramethyl-4-[2-(triphenylphosphonio)acetamido]-1-piperidinyl]oxidanyl Chloride

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

Pubchem Sid

504773195

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773195

Canonical Smiles

CC1(CC(CC(N1O)(C)C)NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Cl-]

IUPAC Name

[2-[(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium;chloride

InChIKey

QJEOOHMMSUBNGG-UHFFFAOYSA-N

INCHI

1S/C29H35N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23,33H,20-22H2,1-4H3;1H

WGK Germany

3

Molecular Weight

511

Reaxy-Rn

34662187

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34662187&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL (196.06 mM); Water: 100 mg/mL (196.06 mM); Ethanol: 100 mg/mL (196.06 mM)
• Sensitivity: Light sensitive；Moisture sensitive；air sensitive；heat sensitive

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1334850-99-5, the molecular formula is C29H36ClN2O2P, and the molecular weight is 511 g/mol. InChIKey QJEOOHMMSUBNGG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.