Bimagrumab (anti-ACVR2B) - Anticuerpo primario, specific to ACVR2B, >95%, Human IgG1, ANTAGONIST of Activin receptor type-2B antagonist, ANTAGONIST of Activin receptor type-2B antagonist

CAS: 1356922-05-8 Cat. No.: Ab176590
Disponible para pedir
GRADE & PURITY Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Humano
Reactive species
Humano, Ratón
Isotype
Human IgG1
Conjugation
Unconjugated
★
Size
Alemania (EU)
USA*
Price
Qty
100μg
Ab176590-100μg
—
Disponible ≥10
80,61€
1mg
Ab176590-1mg
—
4 Disponible
499,73€
5mg
Ab176590-5mg
—
1 Disponible
1.318,88€
10mg
Ab176590-10mg
Fabricado bajo pedido · 8–12 semanas
2.110,25€
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C,Avoid repeated freezing and thawing Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Bimagrumab (anti-ACVR2B) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab (anti-ACVR2B) can be used for the research of pathological muscle loss and weakness.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name
Bimagrumab (anti-ACVR2B) - Anticuerpo primario, specific to ACVR2B, >95%, Human IgG1, ANTAGONIST of Activin receptor type-2B antagonist
Sinónimos
Activin A receptor type IIB antibody | Activin receptor type 2B antibody | Activin receptor type IIB antibody | Activin receptor type-2B antibody | ActR IIB antibody | ACTR-IIB antibody | ActRIIB antibody | ACVR 2B antibody | ACVR2B antibody | AVR2B_HUMAN
Especificaciones y pureza
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Especies hospedadoras
Humano
Especificidad
ACVR2B
Conjugación
Unconjugated
Grado
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Tipo de acción
ANTAGONIST
Mecanismo de acción
ANTAGONIST of Activin receptor type-2B antagonist
Isotipo
Human IgG1
Tipo de cadena ligera
lambdaC2
SDS-PAGE
28.5 kDa (Light Chain) & 50.4 kDa (Heavy Chain), under reducing conditions; 183.3 kDa, under non-reducing conditions.
Método de purificación
Protein A purified
Pureza
>95%
Concentración
See COA
CAS
1356922-05-8
Almacenamiento y envío
Forma
Liquid
Condiciones de almacenamiento de almacenamiento
Store at -80°C,Avoid repeated freezing and thawing
Enviado en
Dry ice packs + Cold packs
Estabilidad y almacenamiento
Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
Imágenes

Bimagrumab (anti-ACVR2B) (Ab176590) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling ACVR2B (red) with Bimagrumab (anti-ACVR2B) (Ab176590). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Bimagrumab (anti-ACVR2B) (Ab176590) - SEC
The purity of Bimagrumab (anti-ACVR2B) (Ab176590) is more than 95% verified by HPLC.

Bimagrumab (anti-ACVR2B) (Ab176590) - ELISA
Immobilized Human ACVR2B-chis at 2.0 μg/mL can bind Bimagrumab (anti-ACVR2B) (Ab176590) with the EC₅₀ of 8.25 ng/mL.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
ACVR2B Tchem Activin receptor type-2B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeFechaArticulo
ZJ24F1113347Certificate of AnalysisAug 04, 2026 Ab176590
ZJ24F1113348Certificate of AnalysisAug 04, 2026 Ab176590
ZJ24F1113349Certificate of AnalysisAug 04, 2026 Ab176590
ZJ26F0737704Certificate of AnalysisJul 23, 2026 Ab176590
ZJ24F0303097Certificate of AnalysisDec 16, 2025 Ab176590
ZJ24F0303098Certificate of AnalysisDec 16, 2025 Ab176590
ZJ24F0303099Certificate of AnalysisDec 16, 2025 Ab176590
Preguntas frecuentes y artículos
Calculadoras de soluciones
Reseñas

Reseñas de cliente

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View Animal Free grade guide → View Carrier Free grade guide → View Recombinant grade guide → View Validated grade guide → View ExactAb™ grade guide → View Low Endotoxin grade guide → View Azide Free grade guide →

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